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Metabolome analysis and chemical profiling of Indonesian royal jellies as the raw material for cosmetic and bio-supplement products

Metabolome analysis and chemical profiling of Indonesian royal jellies as the raw material for cosmetic and bio-supplement products

Posted on September 11, 2021October 7, 2021 by Lindsey

Royal jellies (RJs) possess moisturizing, emulsifying, and stabilizing properties, and a number of pharmacological actions have additionally been discovered to be current, which make them a perfect element for cosmetic and skincare products. Nevertheless, regardless of the considerable efficacies, there’s a lack of research that discover the chemical composition of RJ utilizing metabolome analysis.

Moreover, an analysis of the chemical composition of Indonesian RJs collected from completely different areas has but to be carried out. Due to this fact, the fundamental goal of this examine was to determine any variations in the chemical composition of such RJs. Chemical profiling was additionally carried out to allow extra focused utilization primarily based on the precise compositions.

Chemical profiling can be essential given the wealthy Indonesian biodiversity and the excessive dependence of the RJ compositions on the botanical supply. On this analysis, ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used as half of an untargeted metabolomics method.

From the chemical profiling, >30 compounds have been recognized throughout 4 RJ samples. The key constituents of the samples have been discovered to be oligosaccharides, fatty acids, and adenosine monophosphate derivatives. In the meantime, sucrose and planteose have been discovered to be highest in the samples from Banjarnegara and Kediri, whereas dimethyloctanoic acid was discovered to be distinctive to the pattern from Banjarnegara.

It was additionally found that the RJs from Demak and Tuban contained extra natural fatty acids and oligosaccharides than the different samples. Though the pattern from Demak demonstrated good potential for use in the cosmetic, skincare, and bio-supplement industries, the larger abundance of fatty acids and oligosaccharides in the pattern from Tuban indicated that it’s maybe the best suited RJ for use on this discipline.

Information Mining Approaches for Assessing Chemical Coexposures Utilizing Shopper Product Buy Information

The use of shopper products presents a possible for chemical exposures to people. Toxicity testing and publicity fashions are routinely employed to estimate dangers from their use; nevertheless, a key problem is the sparseness of info regarding who makes use of products and which products are used contemporaneously.

Our objective was to display a way to deduce use patterns by method of buy knowledge. We examined buy patterns for three varieties of private care products (cosmetics, hair care, and skincare) and two family care products (family cleaners and laundry provides) utilizing knowledge from 60,000 households collected over a one-year interval in 2012.

The market basket analysis methodology frequent itemset mining (FIM) was used to determine co-occurring units of product purchases for all households and demographic teams primarily based on revenue, training, race/ethnicity, and household composition. Our methodology captured strong co-occurrence patterns for private and family products, globally and for completely different demographic teams.

FIM recognized cosmetic co-occurrence patterns captured in prior surveys of cosmetic use, as properly as a pattern of elevated variety of cosmetic purchases as youngsters mature to teenage years. We suggest that shopper product buy knowledge may be mined to tell person-oriented use patterns for high-throughput chemical screening purposes, for mixture and mixed chemical danger evaluations.

Chemical Elimination of Lead Corrosion Products

Restoration therapy, specimen preparation or mass loss measurements on coupons made of lead require a dependable course of of dissolution of corrosion products. On this examine, a number of varieties of mannequin corrosion products with compositions consultant of these discovered on actual objects have been ready and characterised.

Ten options have been then totally examined in interval cleansing experiments, relating to the effectivity of removing of the corrosion products, corrosivity in the direction of naked lead, and remnants left on the floor. The answer advisable in the present model of the ISO 8470 customary was discovered to be improper for the cleansing of each historic artefacts and corrosion coupons attributable to its incapability to take away sulfide corrosion products and the danger of floor contamination and staining.

An answer of 20% hydrochloric acid is the best option for the preparation of lead coupons earlier than publicity or for analysis of mass loss of uncovered samples as a result of its considerably larger corrosivity in the direction of metallic lead is tolerable for these purposes.

Metabolome analysis and chemical profiling of AGTC bioproducts with electrophoresis
Accugel gel electrophoresis

Rochelle salt answer was discovered to be optimum for the cleansing of historic artefacts free of sulfide corrosion products attributable to the lowest corrosivity. None of these various options depart remnants on the floor and they’re environment friendly at laboratory temperature.

Figuring out Risky Chemical Product Tracer Compounds in U.S. Cities

With visitors emissions of risky natural compounds (VOCs) reducing quickly over the final a long time, the contributions of the emissions from different supply classes, such as risky chemical products (VCPs), have turn out to be extra obvious in city air. On this work, in situ measurements of numerous VOCs are reported for New York Metropolis, Pittsburgh, Chicago, and Denver.

The magnitude of completely different emission sources relative to visitors is set by measuring the city enhancement of particular person compounds relative to the enhancement of benzene, a recognized tracer of fossil gas in the United States. The enhancement ratios of a number of VCP compounds to benzene correlate properly with inhabitants density (R2 ∼ 0.6-0.8).

These observations are in keeping with the expectation that some human exercise ought to correlate higher with the inhabitants density than transportation emissions, attributable to the decrease per capita fee of driving in denser cities. Utilizing these knowledge, along with a bottom-up fuel-based stock of car emissions and risky chemical products (FIVE-VCP) stock, we determine tracer compounds for completely different VCP classes: decamethylcyclopentasiloxane (D5-siloxane) for private care products, monoterpenes for fragrances, p-dichlorobenzene for pesticides, D4-siloxane for adhesives, para-chlorobenzotrifluoride (PCBTF) for solvent-based coatings, and Texanol for water-based coatings.

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Metomidate Hydrochloride

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Metominostrobin

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(Z)-Metominostrobin

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Description: 133408-51-2

(E)-Metominostrobin

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Desmethylamino Methoxy (Z)-Metominostrobin

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Desmethylamino Methoxy (E)-Metominostrobin

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Metoclopramide HCl

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Metoclopramide HCl

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Metoclopramide HCl

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Metoclopramide HCl

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Metoclopramide HCl

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Metoclopramide HCl

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Metoclopramide HCl

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Metoclopramide HCl

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Metoclopramide HCl

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Metformin HCl

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Metformin HCl

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Metformin HCl

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Metformin HCl

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Metformin HCl

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Methylamine HCl

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Methoxamine HCl

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Methoxamine HCl

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Methoxamine HCl

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Methoxamine HCl

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Methoxamine HCl

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Methoxamine HCl

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Methoxamine HCl

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Methoxamine HCl

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Methyldopate HCl

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Methoxyamine HCl

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Methacycline HCl

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Methacycline HCl

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Methacycline HCl

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Methoxyamine HCl

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Methoxyamine HCl

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Methoxyamine HCl

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Metralindole HCl

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Methoxyamine HCl

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Description: Methoxyamine HCl

Metralindole HCl

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Description: Metralindole HCl

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Methoxetamine HCl

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Methapyrilene HCl

341569 MedKoo Biosciences 100.0mg 240 EUR

Metamfepramone HCl

592206 MedKoo Biosciences 10.0mg 250 EUR

CP 945598 HCl (Otenabant HCl)

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CP 945598 HCl (Otenabant HCl)

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CP 945598 HCl (Otenabant HCl)

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CP 945598 HCl (Otenabant HCl)

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CP 945598 HCl (Otenabant HCl)

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Pazopanib HCl (GW786034 HCl)

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Pazopanib HCl (GW786034 HCl)

MBS579455-10mg MyBiosource 10mg 140 EUR

Pazopanib HCl (GW786034 HCl)

MBS579455-200mg MyBiosource 200mg 285 EUR

Pazopanib HCl (GW786034 HCl)

MBS579455-25mg MyBiosource 25mg 175 EUR

Pazopanib HCl (GW786034 HCl)

MBS579455-50mg MyBiosource 50mg 190 EUR

P005672 HCl (Sarecycline HCl)

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P005672 HCl (Sarecycline HCl)

MBS385970-25mg MyBiosource 25mg 690 EUR

P005672 HCl (Sarecycline HCl)

MBS385970-50mg MyBiosource 50mg 1115 EUR

P005672 HCl (Sarecycline HCl)

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P005672 HCl (Sarecycline HCl)

MBS385970-5x50mg MyBiosource 5x50mg 5015 EUR

Methylisothiazolinone HCl

329834 MedKoo Biosciences 1.0g 250 EUR

AMG-073 HCl (Cinacalcet HCl)

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AMG-073 HCl (Cinacalcet HCl)

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AMG-073 HCl (Cinacalcet HCl)

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AMG-073 HCl (Cinacalcet HCl)

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AMG-073 HCl (Cinacalcet HCl)

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METHYL HYDRAZINE HCL

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Piboserod HCl, SB-207266 HCl

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Piboserod HCl, SB-207266 HCl

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Methapyrilene HCl - 1ML

S-2450 Scientific Laboratory Supplies 1ML 95.85 EUR

Vortioxetine Hcl (Lu AA21004 Hcl)

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Vortioxetine Hcl (Lu AA21004 Hcl)

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3-Methoxytyramine · HCl

4011849.0001 Bachem 1 g 93.24 EUR

3-Methoxytyramine · HCl

4011849.0005 Bachem 5 g 374.12 EUR

3-Methoxytyramine · HCl

Q-1330.0001 Bachem 1.0g 181.2 EUR
Description: Sum Formula: C9H13NO2·HCl; CAS# [1477-68-5]

3-Methoxytyramine · HCl

Q-1330.0005 Bachem 5.0g 618 EUR
Description: Sum Formula: C9H13NO2·HCl; CAS# [1477-68-5]

Methyl leucylleucinate HCl

597431 MedKoo Biosciences 100.0mg 90 EUR

Methyl aminolevulinate HCl

205533 MedKoo Biosciences 100.0mg 150 EUR

Cerubidine (Daunorubicin HCl, Rubidomycin HCl)

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Cerubidine (Daunorubicin HCl, Rubidomycin HCl)

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Methacycline HCl (Physiomycine)

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Methacycline HCl (Physiomycine)

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3-deazaneplanocin A HCl (DZNep HCl)

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3-deazaneplanocin A HCl (DZNep HCl)

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3-deazaneplanocin A HCl (DZNep HCl)

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3-methoxy Tyramine HCl

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3-methoxy Tyramine HCl

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3-methoxy Tyramine HCl

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(R)-2-Methylcysteine HCl

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(R)-2-Methylcysteine HCl

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Description: (R)-2-Methylcysteine HCl

HCl Dilution Matrix (10g/l HCl) - 1L

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Methyl 4-aminobutyrate HCl

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Methyl 4-aminobutyrate HCl

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Methyl 4-aminobutyrate HCl

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Methyl 4-aminobutyrate HCl

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Methyl 4-aminobutyrate HCl

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OOMC00047-5G - Metformin HCl

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A3 HCl

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ZM 39923 HCl

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Description: Chromatin/Epigenetics|JAK#JAK/STAT Signaling|JAK

A 410099.1 HCl

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GR 127935 HCl

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RS 100329 HCl

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RS 17053 HCl

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RS 67333 HCl

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(+)-PD 128907 HCl

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DAU 5884 HCl

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CGS 21680 HCl

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Description: GPCR/G protein|Adenosine Receptor

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Description: GPCR/G protein|Adenosine Receptor

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Description: GPCR/G protein|Adenosine Receptor

CGS 21680 HCl

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Description: GPCR/G protein|Adenosine Receptor

ZM 323881 HCl

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Description: Tyrosine Kinase|c-MET

ZM 323881 HCl

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Description: ZM323881 is a novel VEGF-R2 selective inhibitor with IC50 of <2nM.

ZM 323881 HCl

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Description: Tyrosine Kinase|c-MET

RS 127445 HCl

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Description: Neuroscience|5-HT Receptor

RS 127445 HCl

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Description: Neuroscience|5-HT Receptor

RS 127445 HCl

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Description: Neuroscience|5-HT Receptor

RS 127445 HCl

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Description: Neuroscience|5-HT Receptor

WAY 316606 HCl

B8302-10 ApexBio 10 mg 244 EUR
Description: Others|sFRP-1

WAY 316606 HCl

B8302-100 ApexBio 100 mg 1445.6 EUR
Description: Others|sFRP-1

WAY 316606 HCl

B8302-5 ApexBio 5 mg 141.6 EUR
Description: Others|sFRP-1

WAY 316606 HCl

B8302-50 ApexBio 50 mg 904 EUR
Description: Others|sFRP-1

PD 0332991 HCl

MBS132091-100mg MyBiosource 100mg 1065 EUR

PD 0332991 HCl

MBS132091-500mg MyBiosource 500mg 2775 EUR

SB 258585 HCl

MBS3840157-10mg MyBiosource 10mg 210 EUR

SB 258585 HCl

MBS3840157-25mg MyBiosource 25mg 345 EUR

SB 258585 HCl

MBS3840157-50mg MyBiosource 50mg 520 EUR

SB 258585 HCl

MBS3840157-5x50mg MyBiosource 5x50mg 2335 EUR

TG 100572 HCl

MBS3840967-10mg MyBiosource 10mg 475 EUR

TG 100572 HCl

MBS3840967-25mg MyBiosource 25mg 1095 EUR

TG 100572 HCl

MBS3840967-5mg MyBiosource 5mg 300 EUR

TG 100572 HCl

MBS3840967-5x25mg MyBiosource 5x25mg 4915 EUR

TG 100801 HCl

MBS3840968-10mg MyBiosource 10mg 475 EUR

TG 100801 HCl

MBS3840968-25mg MyBiosource 25mg 1095 EUR

TG 100801 HCl

MBS3840968-5mg MyBiosource 5mg 300 EUR

TG 100801 HCl

MBS3840968-5x25mg MyBiosource 5x25mg 4915 EUR

SCH 23390 HCl

MBS384001-10mg MyBiosource 10mg 190 EUR

SCH 23390 HCl

MBS384001-25mg MyBiosource 25mg 300 EUR
×

Moreover, a number of different compounds are recognized (e.g., ethanol) that correlate with inhabitants density and originate from a number of VCP sources. Ethanol and fragrances are amongst the most considerable and reactive VOCs related to VCP emissions.

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