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Metabolome analysis and chemical profiling of Indonesian royal jellies as the raw material for cosmetic and bio-supplement products

Metabolome analysis and chemical profiling of Indonesian royal jellies as the raw material for cosmetic and bio-supplement products

Posted on September 11, 2021October 7, 2021 by Lindsey

Royal jellies (RJs) possess moisturizing, emulsifying, and stabilizing properties, and a number of pharmacological actions have additionally been discovered to be current, which make them a perfect element for cosmetic and skincare products. Nevertheless, regardless of the considerable efficacies, there’s a lack of research that discover the chemical composition of RJ utilizing metabolome analysis.

Moreover, an analysis of the chemical composition of Indonesian RJs collected from completely different areas has but to be carried out. Due to this fact, the fundamental goal of this examine was to determine any variations in the chemical composition of such RJs. Chemical profiling was additionally carried out to allow extra focused utilization primarily based on the precise compositions.

Chemical profiling can be essential given the wealthy Indonesian biodiversity and the excessive dependence of the RJ compositions on the botanical supply. On this analysis, ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used as half of an untargeted metabolomics method.

From the chemical profiling, >30 compounds have been recognized throughout 4 RJ samples. The key constituents of the samples have been discovered to be oligosaccharides, fatty acids, and adenosine monophosphate derivatives. In the meantime, sucrose and planteose have been discovered to be highest in the samples from Banjarnegara and Kediri, whereas dimethyloctanoic acid was discovered to be distinctive to the pattern from Banjarnegara.

It was additionally found that the RJs from Demak and Tuban contained extra natural fatty acids and oligosaccharides than the different samples. Though the pattern from Demak demonstrated good potential for use in the cosmetic, skincare, and bio-supplement industries, the larger abundance of fatty acids and oligosaccharides in the pattern from Tuban indicated that it’s maybe the best suited RJ for use on this discipline.

Information Mining Approaches for Assessing Chemical Coexposures Utilizing Shopper Product Buy Information

The use of shopper products presents a possible for chemical exposures to people. Toxicity testing and publicity fashions are routinely employed to estimate dangers from their use; nevertheless, a key problem is the sparseness of info regarding who makes use of products and which products are used contemporaneously.

Our objective was to display a way to deduce use patterns by method of buy knowledge. We examined buy patterns for three varieties of private care products (cosmetics, hair care, and skincare) and two family care products (family cleaners and laundry provides) utilizing knowledge from 60,000 households collected over a one-year interval in 2012.

The market basket analysis methodology frequent itemset mining (FIM) was used to determine co-occurring units of product purchases for all households and demographic teams primarily based on revenue, training, race/ethnicity, and household composition. Our methodology captured strong co-occurrence patterns for private and family products, globally and for completely different demographic teams.

FIM recognized cosmetic co-occurrence patterns captured in prior surveys of cosmetic use, as properly as a pattern of elevated variety of cosmetic purchases as youngsters mature to teenage years. We suggest that shopper product buy knowledge may be mined to tell person-oriented use patterns for high-throughput chemical screening purposes, for mixture and mixed chemical danger evaluations.

Chemical Elimination of Lead Corrosion Products

Restoration therapy, specimen preparation or mass loss measurements on coupons made of lead require a dependable course of of dissolution of corrosion products. On this examine, a number of varieties of mannequin corrosion products with compositions consultant of these discovered on actual objects have been ready and characterised.

Ten options have been then totally examined in interval cleansing experiments, relating to the effectivity of removing of the corrosion products, corrosivity in the direction of naked lead, and remnants left on the floor. The answer advisable in the present model of the ISO 8470 customary was discovered to be improper for the cleansing of each historic artefacts and corrosion coupons attributable to its incapability to take away sulfide corrosion products and the danger of floor contamination and staining.

An answer of 20% hydrochloric acid is the best option for the preparation of lead coupons earlier than publicity or for analysis of mass loss of uncovered samples as a result of its considerably larger corrosivity in the direction of metallic lead is tolerable for these purposes.

Metabolome analysis and chemical profiling of AGTC bioproducts with electrophoresis
Accugel gel electrophoresis

Rochelle salt answer was discovered to be optimum for the cleansing of historic artefacts free of sulfide corrosion products attributable to the lowest corrosivity. None of these various options depart remnants on the floor and they’re environment friendly at laboratory temperature.

Figuring out Risky Chemical Product Tracer Compounds in U.S. Cities

With visitors emissions of risky natural compounds (VOCs) reducing quickly over the final a long time, the contributions of the emissions from different supply classes, such as risky chemical products (VCPs), have turn out to be extra obvious in city air. On this work, in situ measurements of numerous VOCs are reported for New York Metropolis, Pittsburgh, Chicago, and Denver.

The magnitude of completely different emission sources relative to visitors is set by measuring the city enhancement of particular person compounds relative to the enhancement of benzene, a recognized tracer of fossil gas in the United States. The enhancement ratios of a number of VCP compounds to benzene correlate properly with inhabitants density (R2 ∼ 0.6-0.8).

These observations are in keeping with the expectation that some human exercise ought to correlate higher with the inhabitants density than transportation emissions, attributable to the decrease per capita fee of driving in denser cities. Utilizing these knowledge, along with a bottom-up fuel-based stock of car emissions and risky chemical products (FIVE-VCP) stock, we determine tracer compounds for completely different VCP classes: decamethylcyclopentasiloxane (D5-siloxane) for private care products, monoterpenes for fragrances, p-dichlorobenzene for pesticides, D4-siloxane for adhesives, para-chlorobenzotrifluoride (PCBTF) for solvent-based coatings, and Texanol for water-based coatings.

Minocycline Hcl

abx188790-10g Abbexa 10 g
EUR 773

Naphazoline Hcl

abx188809-1000g Abbexa 1000 g
EUR 1720

Daunorubicin HCl

ADC-P-080 Creative Biolabs unit Ask for price

Cyclobenzaprine HCl

20-abx180713 Abbexa
  • EUR 244.00
  • EUR 328.00
  • EUR 787.00
  • 100 mg
  • 1 g
  • 5 g

Tamsulosin HCl

20-abx180875 Abbexa
  • EUR 398.00
  • EUR 634.00
  • 100 mg
  • 250 mg

Decloxizini HCl

20-abx181258 Abbexa
  • EUR 286.00
  • EUR 871.00
  • EUR 398.00
  • 100 mg
  • 1 g
  • 250 mg

Meclofenoxate HCl

abx181309-100g Abbexa 100 g
EUR 356

Cyclopentanemethylamine HCl

20-abx182408 Abbexa
  • EUR 453.00
  • EUR 2764.00
  • EUR 1038.00
  • 1 g
  • 25 g
  • 5 g

Antazoline HCl

abx183853-25g Abbexa 25 g
EUR 286

Benzydamine HCl

abx183874-10g Abbexa 10 g
EUR 411

Ciprofloxacin HCl

20-abx183943 Abbexa
  • EUR 495.00
  • EUR 189.00
  • EUR 272.00
  • EUR 203.00
  • 100 g
  • 1 g
  • 25 g
  • 5 g

Doxepin HCl

20-abx184015 Abbexa
  • EUR 1107.00
  • EUR 203.00
  • EUR 509.00
  • EUR 286.00
  • 100 g
  • 1 g
  • 25 g
  • 5 g

Doxorubicin HCl

20-abx184016 Abbexa
  • EUR 746.00
  • EUR 1483.00
  • 1 g
  • 5 g

Doxycycline HCl

20-abx184017 Abbexa
  • EUR 676.00
  • EUR 342.00
  • 100 g
  • 25 g

Isoprenaline HCl

20-abx184138 Abbexa
  • EUR 217.00
  • EUR 690.00
  • EUR 314.00
  • 1 g
  • 25 g
  • 5 g

Octopamine HCl

20-abx184289 Abbexa
  • EUR 314.00
  • EUR 203.00
  • EUR 481.00
  • EUR 258.00
  • 10 g
  • 1 g
  • 25 g
  • 5 g

Pd128907 Hcl

20-abx184299 Abbexa
  • EUR 453.00
  • EUR 328.00
  • 10 mg
  • 5 mg

Propranolol HCl

abx184325-1g Abbexa 1 g
EUR 189

Terbinafine HCl

20-abx184395 Abbexa
  • EUR 286.00
  • EUR 175.00
  • EUR 203.00
  • 100 g
  • 1 g
  • 25 g

Atomoxetine HCl

20-abx184648 Abbexa
  • EUR 328.00
  • EUR 634.00
  • 1 g
  • 5 g

Procaine HCl

20-abx184762 Abbexa
  • EUR 244.00
  • EUR 481.00
  • 100 g
  • 500 g

Thiamine HCl

20-abx184786 Abbexa
  • EUR 244.00
  • EUR 439.00
  • 100 g
  • 500 g

EDC-HCl

20-abx095087 Abbexa
  • EUR 509.00
  • EUR 370.00
  • 1 kg
  • 500 g

Verapamil HCl

20-abx076503 Abbexa
  • EUR 217.00
  • EUR 300.00
  • 1 g
  • 5 g

Duloxetine HCl

20-abx076532 Abbexa
  • EUR 244.00
  • EUR 453.00
  • 10 mg
  • 50 mg

Puromycin HCl

20-abx076662 Abbexa
  • EUR 439.00
  • EUR 230.00
  • 250 mg
  • 50 mg

Nicardipine HCl

20-abx076668 Abbexa
  • EUR 300.00
  • EUR 230.00
  • 250 mg
  • 50 mg

Ambroxol HCl

20-abx076696 Abbexa
  • EUR 314.00
  • EUR 258.00
  • 500 mg
  • 50 mg

Irinotecan HCl

20-abx076771 Abbexa
  • EUR 718.00
  • EUR 314.00
  • 250 mg
  • 50 mg

Tetracyclin Hcl

abx082256-5g Abbexa 5 g
EUR 189

Guanidine Hcl

abx082517-500g Abbexa 500 g
EUR 189

Tris-Hcl

20-abx082568 Abbexa
  • EUR 189.00
  • EUR 230.00
  • 100 g
  • 500 g

Tetracyclin Hcl

abx082590-5g Abbexa 5 g
EUR 175

Levofloxacin HCl

L048-1G TOKU-E 1g
EUR 58

Levofloxacin HCl

L048-5G TOKU-E 5g
EUR 97

Tris-Hcl

T9201-100 GenDepot 1Kg
EUR 296

Ondansetron HCl

A5166-10 ApexBio 10 mg
EUR 108
Description: Ondansetron hydrochloride dihydrate is a serotonin-3 (5-HT3) receptor antagonist.

Ondansetron HCl

A5166-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 131
Description: Ondansetron hydrochloride dihydrate is a serotonin-3 (5-HT3) receptor antagonist.

Ondansetron HCl

A5166-50 ApexBio 50 mg
EUR 148
Description: Ondansetron hydrochloride dihydrate is a serotonin-3 (5-HT3) receptor antagonist.

Alfuzosin HCl

A5173-100 ApexBio 100 mg
EUR 398
Description: Functionally uro-selective ?1 adrenoceptor antagonist that does not discriminate between ?1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascula

Alfuzosin HCl

A5173-25 ApexBio 25 mg
EUR 166
Description: Functionally uro-selective ?1 adrenoceptor antagonist that does not discriminate between ?1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascula

Alfuzosin HCl

A5173-5 ApexBio 5 mg
EUR 108
Description: Functionally uro-selective ?1 adrenoceptor antagonist that does not discriminate between ?1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascula

Alfuzosin HCl

A5173-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 155
Description: Functionally uro-selective ?1 adrenoceptor antagonist that does not discriminate between ?1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascula

Prazosin HCl

A5318-100 ApexBio 100 mg
EUR 166
Description: ?1 and ?2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). Also available as part of the ?1-Adrenoceptor Tocriset? and Mixed Adre

Prazosin HCl

A5318-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 108
Description: ?1 and ?2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). Also available as part of the ?1-Adrenoceptor Tocriset? and Mixed Adre

Moxifloxacin HCl

A5323-200 ApexBio 200 mg
EUR 224
Description: Moxifloxacin HCl is anti-infective compound with a broad antibacterial spectrum.[1] Moxifloxacin is a fourth generation fluoroquinolone antibacterial agent with a broad antibacterial spectrum against Gram positive bacteria and Gram negative bacteria in vitro.

Moxifloxacin HCl

A5323-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 113
Description: Moxifloxacin HCl is anti-infective compound with a broad antibacterial spectrum.[1] Moxifloxacin is a fourth generation fluoroquinolone antibacterial agent with a broad antibacterial spectrum against Gram positive bacteria and Gram negative bacteria in vitro.

Moxifloxacin HCl

A5323-50 ApexBio 50 mg
EUR 108
Description: Moxifloxacin HCl is anti-infective compound with a broad antibacterial spectrum.[1] Moxifloxacin is a fourth generation fluoroquinolone antibacterial agent with a broad antibacterial spectrum against Gram positive bacteria and Gram negative bacteria in vitro.

Ziprasidone HCl

A5350-100 ApexBio 100 mg
EUR 166
Description: Atypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT2A receptors with a 5-HT2A/D2 affinity ratio greater than any other clinically available atypical antipsychotics (pKi values are 9.38,

Ziprasidone HCl

A5350-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 119
Description: Atypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT2A receptors with a 5-HT2A/D2 affinity ratio greater than any other clinically available atypical antipsychotics (pKi values are 9.38,

Arbidol HCl

A8362-10 ApexBio 10 mg
EUR 108
Description: Arbidol (Umifenovir) hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane.

Arbidol HCl

A8362-100 ApexBio 100 mg
EUR 351
Description: Arbidol (Umifenovir) hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane.

Arbidol HCl

A8362-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 113
Description: Arbidol (Umifenovir) hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane.

Conivaptan HCl

A8402-10 ApexBio 10 mg
EUR 139
Description: Conivaptan Hydrochloride is a non-peptide inhibitor of antidiuretic hormone. Conivaptan Hydrochloride is used for treatment of congestive heart failure.

Conivaptan HCl

A8402-100 ApexBio 100 mg
EUR 674
Description: Conivaptan Hydrochloride is a non-peptide inhibitor of antidiuretic hormone. Conivaptan Hydrochloride is used for treatment of congestive heart failure.

Conivaptan HCl

A8402-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 151
Description: Conivaptan Hydrochloride is a non-peptide inhibitor of antidiuretic hormone. Conivaptan Hydrochloride is used for treatment of congestive heart failure.

Dicyclomine HCl

A8409-1000 ApexBio 1 g
EUR 431
Description: Used as a gastrointestinal antispasmodic antacid.

Dicyclomine HCl

A8409-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 108
Description: Used as a gastrointestinal antispasmodic antacid.

Dicyclomine HCl

A8409-5000 ApexBio 5 g
EUR 999
Description: Used as a gastrointestinal antispasmodic antacid.

Difloxacin HCl

A8411-1000 ApexBio 1 g
EUR 119
Description: Difloxacin HCl is a quinolone antimicrobial antibiotic [1]. Quinolone antibiotics target bacterial DNA gyrase which is required during DNA replication, subsequent DNA synthesis and ultimately cell division.

Difloxacin HCl

A8411-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 108
Description: Difloxacin HCl is a quinolone antimicrobial antibiotic [1]. Quinolone antibiotics target bacterial DNA gyrase which is required during DNA replication, subsequent DNA synthesis and ultimately cell division.

Difloxacin HCl

A8411-5000 ApexBio 5 g
EUR 251
Description: Difloxacin HCl is a quinolone antimicrobial antibiotic [1]. Quinolone antibiotics target bacterial DNA gyrase which is required during DNA replication, subsequent DNA synthesis and ultimately cell division.

Diperodon HCl

A8413-100 ApexBio 100 mg
EUR 108
Description: Diperodon HCl

Diperodon HCl

A8413-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 108
Description: Diperodon HCl

Diphenylpyraline HCl

A8415-1000 ApexBio 1 g
EUR 431
Description: Diphenylpyraline is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class.

Diphenylpyraline HCl

A8415-10000 ApexBio 10 g
EUR 1486
Description: Diphenylpyraline is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class.

Diphenylpyraline HCl

A8415-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 108
Description: Diphenylpyraline is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class.

Diphenylpyraline HCl

A8415-5000 ApexBio 5 g
EUR 999
Description: Diphenylpyraline is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class.

Doxapram HCl

A8419-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 142
Description: Doxapram HCl is a respiratory stimulant.

Doxapram HCl

A8419-50 ApexBio 50 mg
EUR 131
Description: Doxapram HCl is a respiratory stimulant.

Doxycycline HCl

A8420-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 108
Description: Doxycycline Hydrochloride is a synthetic tetracycline derivative with similar antimicrobial activity.Doxycycline is a tetracycline antibiotic which is commonly used to treat a variety of infections. Doxycycline treatment resulted in a 96% loss of Wolbachi

Doxycycline HCl

A8420-50 ApexBio 50 mg
EUR 131
Description: Doxycycline Hydrochloride is a synthetic tetracycline derivative with similar antimicrobial activity.Doxycycline is a tetracycline antibiotic which is commonly used to treat a variety of infections. Doxycycline treatment resulted in a 96% loss of Wolbachi

Duloxetine HCl

A8421-10 ApexBio 10 mg
EUR 139
Description: Duloxetine HCl is a selective serotonin and norepinephrine reuptake inhibitor .

Duloxetine HCl

A8421-100 ApexBio 100 mg
EUR 674
Description: Duloxetine HCl is a selective serotonin and norepinephrine reuptake inhibitor .

Duloxetine HCl

A8421-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 113
Description: Duloxetine HCl is a selective serotonin and norepinephrine reuptake inhibitor .

Ethambutol HCl

A8427-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 113
Description: Nocodazole is a tubulin production inhibitor, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 value of 0.21 ?M, 0.53 ?M and 0.64 ?M, respectively [1].Nocodazole is an inhibitor of microtubule polymerization which inhibits insulin-stimulated glucose transport.

Ethambutol HCl

A8427-50 ApexBio 50 mg
EUR 131
Description: Nocodazole is a tubulin production inhibitor, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 value of 0.21 ?M, 0.53 ?M and 0.64 ?M, respectively [1].Nocodazole is an inhibitor of microtubule polymerization which inhibits insulin-stimulated glucose transport.

GW3965 HCl

A8444-10 ApexBio 10 mg
EUR 171
Description: GW3965 HCl is a selective, orally active non-steroidal agonist for the liver X receptor (LXR) [1].Nuclear receptors LXR? and LXR? have an important role in control of cholesterol and fatty acid metabolism in multiple cell types.

GW3965 HCl

A8444-5 ApexBio 5 mg
EUR 129
Description: GW3965 HCl is a selective, orally active non-steroidal agonist for the liver X receptor (LXR) [1].Nuclear receptors LXR? and LXR? have an important role in control of cholesterol and fatty acid metabolism in multiple cell types.

GW3965 HCl

A8444-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 166
Description: GW3965 HCl is a selective, orally active non-steroidal agonist for the liver X receptor (LXR) [1].Nuclear receptors LXR? and LXR? have an important role in control of cholesterol and fatty acid metabolism in multiple cell types.

GW3965 HCl

A8444-50 ApexBio 50 mg
EUR 512
Description: GW3965 HCl is a selective, orally active non-steroidal agonist for the liver X receptor (LXR) [1].Nuclear receptors LXR? and LXR? have an important role in control of cholesterol and fatty acid metabolism in multiple cell types.

Imidapril HCl

A8447-10 ApexBio 10 mg
EUR 108
Description: Imidapril (INN) is an ACE inhibitor used as an antihypertensive drug and for the treatment of chronic heart failure.

Imidapril HCl

A8447-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 126
Description: Imidapril (INN) is an ACE inhibitor used as an antihypertensive drug and for the treatment of chronic heart failure.

Imidapril HCl

A8447-50 ApexBio 50 mg
EUR 229
Description: Imidapril (INN) is an ACE inhibitor used as an antihypertensive drug and for the treatment of chronic heart failure.

Noscapine HCl

A8479-1000 ApexBio 1 g
EUR 431
Description: Noscapine hydrochloride is the hydrochloride form of Noscapine. Noscapine is an opioid alkaloid with several actions. Antagonist at Bradykinin B Receptor (bradykinin receptors) , inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues.

Noscapine HCl

A8479-10000 ApexBio 10 g
EUR 1486
Description: Noscapine hydrochloride is the hydrochloride form of Noscapine. Noscapine is an opioid alkaloid with several actions. Antagonist at Bradykinin B Receptor (bradykinin receptors) , inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues.

Noscapine HCl

A8479-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 108
Description: Noscapine hydrochloride is the hydrochloride form of Noscapine. Noscapine is an opioid alkaloid with several actions. Antagonist at Bradykinin B Receptor (bradykinin receptors) , inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues.

Noscapine HCl

A8479-5000 ApexBio 5 g
EUR 999
Description: Noscapine hydrochloride is the hydrochloride form of Noscapine. Noscapine is an opioid alkaloid with several actions. Antagonist at Bradykinin B Receptor (bradykinin receptors) , inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues.

Thioridazine HCl

A8537-1000 ApexBio 1 g
EUR 189
Description: Thioridazine·HCl is a calcium channel protein inhibitor as well as D2DR/D4DR inhibitor. Its administration has been associated with hypotension. It has also been, after chronic treatment, used to test increased sensitivity of dopaminergic agents.

Thioridazine HCl

A8537-5 ApexBio 5 mg
EUR 108
Description: Thioridazine·HCl is a calcium channel protein inhibitor as well as D2DR/D4DR inhibitor. Its administration has been associated with hypotension. It has also been, after chronic treatment, used to test increased sensitivity of dopaminergic agents.

Thioridazine HCl

A8537-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 113
Description: Thioridazine·HCl is a calcium channel protein inhibitor as well as D2DR/D4DR inhibitor. Its administration has been associated with hypotension. It has also been, after chronic treatment, used to test increased sensitivity of dopaminergic agents.

Granisetron HCl

A1295-100 ApexBio 100 mg
EUR 189
Description: 5-HT3 receptor antagonist that possesses potent antiemetic activity.

Granisetron HCl

A1295-5 ApexBio 5 mg
EUR 108
Description: 5-HT3 receptor antagonist that possesses potent antiemetic activity.

Granisetron HCl

A1295-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 119
Description: 5-HT3 receptor antagonist that possesses potent antiemetic activity.

Granisetron HCl

A1295-50 ApexBio 50 mg
EUR 131
Description: 5-HT3 receptor antagonist that possesses potent antiemetic activity.

Gemcitabine HCl

A1402-100 ApexBio 100 mg
EUR 108
Description: Gemcitabine HCl is an inhibitor of DNA synthesis with the IC50 value of 240.4±29.0 ?M (CCRF-CEM/dCK-/- cells), 14.7±2.8 nM (TC-1 cells), 36.7 ± 5.1 ?M (TC-1-GR cells), and 50 nM (PANC1 cells).

Gemcitabine HCl

A1402-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 108
Description: Gemcitabine HCl is an inhibitor of DNA synthesis with the IC50 value of 240.4±29.0 ?M (CCRF-CEM/dCK-/- cells), 14.7±2.8 nM (TC-1 cells), 36.7 ± 5.1 ?M (TC-1-GR cells), and 50 nM (PANC1 cells).

Mianserin HCl

A1796-100 ApexBio 100 mg
EUR 282
Description: Non-selective 5-HT2 receptor antagonist. Has moderate affinity for 5-HT6. Antidepressant.

Mianserin HCl

A1796-5 ApexBio 5 mg
EUR 108
Description: Non-selective 5-HT2 receptor antagonist. Has moderate affinity for 5-HT6. Antidepressant.

Mianserin HCl

A1796-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 126
Description: Non-selective 5-HT2 receptor antagonist. Has moderate affinity for 5-HT6. Antidepressant.

Bendamustine HCl

A1984-10 ApexBio 10 mg
EUR 166
Description: Bendamustine HCl is an alkylating agent associated with DNA damage with IC50 of 50 ?M [1]. It has been reported that bendamustine is activated under DNA damage stress and apoptosis.

Bendamustine HCl

A1984-5 ApexBio 5 mg
EUR 108
Description: Bendamustine HCl is an alkylating agent associated with DNA damage with IC50 of 50 ?M [1]. It has been reported that bendamustine is activated under DNA damage stress and apoptosis.

Bendamustine HCl

A1984-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 154
Description: Bendamustine HCl is an alkylating agent associated with DNA damage with IC50 of 50 ?M [1]. It has been reported that bendamustine is activated under DNA damage stress and apoptosis.

Fluoxetine HCl

A2436-100 ApexBio 100 mg
EUR 148
Description: Fluoxetine is a specific presynaptic serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.The serotonin receptor, also known as 5-HT receptor, is a member of G protein-coupled receptorfound in the central and peripheral nervous systems.

Fluoxetine HCl

A2436-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 142
Description: Fluoxetine is a specific presynaptic serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.The serotonin receptor, also known as 5-HT receptor, is a member of G protein-coupled receptorfound in the central and peripheral nervous systems.

Fluoxetine HCl

A2436-500 ApexBio 500 mg
EUR 328
Description: Fluoxetine is a specific presynaptic serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.The serotonin receptor, also known as 5-HT receptor, is a member of G protein-coupled receptorfound in the central and peripheral nervous systems.

Epirubicin HCl

A2451-100 ApexBio 100 mg
EUR 467
Description: Epirubicin is an inhibitor of DNA topoisomerase (TOPII) [1].Epirubicin belongs to the Anthracylines chemical class, it is a sort of DNA topoisomerase poison.

Epirubicin HCl

A2451-25 ApexBio 25 mg
EUR 258
Description: Epirubicin is an inhibitor of DNA topoisomerase (TOPII) [1].Epirubicin belongs to the Anthracylines chemical class, it is a sort of DNA topoisomerase poison.

Epirubicin HCl

A2451-5 ApexBio 5 mg
EUR 102
Description: Epirubicin is an inhibitor of DNA topoisomerase (TOPII) [1].Epirubicin belongs to the Anthracylines chemical class, it is a sort of DNA topoisomerase poison.

Epirubicin HCl

A2451-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 123
Description: Epirubicin is an inhibitor of DNA topoisomerase (TOPII) [1].Epirubicin belongs to the Anthracylines chemical class, it is a sort of DNA topoisomerase poison.

Idarubicin HCl

A2476-100 ApexBio 100 mg
EUR 572
Description: Idarubicin is an inhibitor of DNA topoisomerase II [1].Idarubicin is a synthetic anthracycline anticancer drug widely used in the treatment of acute myelogenous leukemia and some other hematological malignancies.

Idarubicin HCl

A2476-25 ApexBio 25 mg
EUR 224
Description: Idarubicin is an inhibitor of DNA topoisomerase II [1].Idarubicin is a synthetic anthracycline anticancer drug widely used in the treatment of acute myelogenous leukemia and some other hematological malignancies.

Idarubicin HCl

A2476-5 ApexBio 5 mg
EUR 108
Description: Idarubicin is an inhibitor of DNA topoisomerase II [1].Idarubicin is a synthetic anthracycline anticancer drug widely used in the treatment of acute myelogenous leukemia and some other hematological malignancies.

Idarubicin HCl

A2476-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 142
Description: Idarubicin is an inhibitor of DNA topoisomerase II [1].Idarubicin is a synthetic anthracycline anticancer drug widely used in the treatment of acute myelogenous leukemia and some other hematological malignancies.

ADL5859 HCl

A2986-100 ApexBio 100 mg
EUR 1186
Description: Selective ? opioid receptor agonists are promising potential therapeutic agents for the treatment of various types of pain conditions. A spirocyclic derivative was identified as a promising hit through screening.

ADL5859 HCl

A2986-25 ApexBio 25 mg
EUR 490
Description: Selective ? opioid receptor agonists are promising potential therapeutic agents for the treatment of various types of pain conditions. A spirocyclic derivative was identified as a promising hit through screening.

ADL5859 HCl

A2986-5 ApexBio 5 mg
EUR 189
Description: Selective ? opioid receptor agonists are promising potential therapeutic agents for the treatment of various types of pain conditions. A spirocyclic derivative was identified as a promising hit through screening.

ADL5859 HCl

A2986-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 218
Description: Selective ? opioid receptor agonists are promising potential therapeutic agents for the treatment of various types of pain conditions. A spirocyclic derivative was identified as a promising hit through screening.

LY2606368 HCl

B8313-25 ApexBio 25 mg
EUR 815
Description: LY2606368 HCl is a selective ATP competitive inhibitor of checkpoint kinase 1(CHK1) with IC50 value of 1.5nM in SW1990 cells [1].CHK1 is an intracellular serine/threonine kinase that plays a role in DNA damage response pathway.

LY2606368 HCl

B8313-5 ApexBio 5 mg
EUR 305
Description: LY2606368 HCl is a selective ATP competitive inhibitor of checkpoint kinase 1(CHK1) with IC50 value of 1.5nM in SW1990 cells [1].CHK1 is an intracellular serine/threonine kinase that plays a role in DNA damage response pathway.

SRT1720 HCl

A4180-10 ApexBio 10 mg
EUR 258
Description: SRT1720 is a small-molecule compound which has the ability of activating the sirtuin subtype SIRT1 in vitro. The activity of SRT1720 as a SIRT1 activator is stronger than that of resveratrol.

SRT1720 HCl

A4180-200 ApexBio 200 mg
EUR 1442
Description: SRT1720 is a small-molecule compound which has the ability of activating the sirtuin subtype SIRT1 in vitro. The activity of SRT1720 as a SIRT1 activator is stronger than that of resveratrol.

SRT1720 HCl

A4180-5 ApexBio 5 mg
EUR 177
Description: SRT1720 is a small-molecule compound which has the ability of activating the sirtuin subtype SIRT1 in vitro. The activity of SRT1720 as a SIRT1 activator is stronger than that of resveratrol.

SRT1720 HCl

A4180-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 189
Description: SRT1720 is a small-molecule compound which has the ability of activating the sirtuin subtype SIRT1 in vitro. The activity of SRT1720 as a SIRT1 activator is stronger than that of resveratrol.

SRT1720 HCl

A4180-50 ApexBio 50 mg
EUR 688
Description: SRT1720 is a small-molecule compound which has the ability of activating the sirtuin subtype SIRT1 in vitro. The activity of SRT1720 as a SIRT1 activator is stronger than that of resveratrol.

SRT1720 HCl

A4180-S ApexBio Evaluation Sample
EUR 81
Description: SRT1720 is a small-molecule compound which has the ability of activating the sirtuin subtype SIRT1 in vitro. The activity of SRT1720 as a SIRT1 activator is stronger than that of resveratrol.

Rosiglitazone HCl

A4310-100 ApexBio 100 mg
EUR 131
Description: Rosiglitazone is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.

Rosiglitazone HCl

A4310-200 ApexBio 200 mg
EUR 177
Description: Rosiglitazone is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.

Rosiglitazone HCl

A4310-25 ApexBio 25 mg
EUR 108
Description: Rosiglitazone is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.

Pioglitazone HCl

A4324-10 ApexBio 10 mg
EUR 119
Description: Pioglitazone HCl is a potent and highly selective agonist of PPAR? with IC50 value of 3?M[1].Pioglitazone HCl can increase both insulin-stimulated glucose uptake in peripheral tissues and insulin sensitivity in hepatic and adipose tissue.

Pioglitazone HCl

A4324-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 108
Description: Pioglitazone HCl is a potent and highly selective agonist of PPAR? with IC50 value of 3?M[1].Pioglitazone HCl can increase both insulin-stimulated glucose uptake in peripheral tissues and insulin sensitivity in hepatic and adipose tissue.

Pioglitazone HCl

A4324-50 ApexBio 50 mg
EUR 166
Description: Pioglitazone HCl is a potent and highly selective agonist of PPAR? with IC50 value of 3?M[1].Pioglitazone HCl can increase both insulin-stimulated glucose uptake in peripheral tissues and insulin sensitivity in hepatic and adipose tissue.

Anagrelide HCl

A4352-10 ApexBio 10 mg
EUR 102
Description: Anagrelide is a selective thrombocytopenic agent [1].Anagrelide is a FDA-approved drug for the treatment of essential thrombocythemia. It is originally identified as a potential inhibitor of platelet aggregation.

Anagrelide HCl

A4352-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 108
Description: Anagrelide is a selective thrombocytopenic agent [1].Anagrelide is a FDA-approved drug for the treatment of essential thrombocythemia. It is originally identified as a potential inhibitor of platelet aggregation.

Anagrelide HCl

A4352-50 ApexBio 50 mg
EUR 235
Description: Anagrelide is a selective thrombocytopenic agent [1].Anagrelide is a FDA-approved drug for the treatment of essential thrombocythemia. It is originally identified as a potential inhibitor of platelet aggregation.

Dorzolamide HCl

A4357-10 ApexBio 10 mg
EUR 128
Description: Dorzolamide HCl is a carbonic anhydrase inhibitor.

Dorzolamide HCl

A4357-100 ApexBio 100 mg
EUR 435
Description: Dorzolamide HCl is a carbonic anhydrase inhibitor.

Dorzolamide HCl

A4357-25 ApexBio 25 mg
EUR 171
Description: Dorzolamide HCl is a carbonic anhydrase inhibitor.

Dorzolamide HCl

A4357-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 108
Description: Dorzolamide HCl is a carbonic anhydrase inhibitor.

Dorzolamide HCl

A4357-50 ApexBio 50 mg
EUR 282
Description: Dorzolamide HCl is a carbonic anhydrase inhibitor.

Paroxetine HCl

B2252-10 ApexBio 10 mg
EUR 108
Description: Paroxetine Hydrochloride is a antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs).Paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake. Paroxetine likely inhibits the reuptake of serotonin at the

Paroxetine HCl

B2252-100 ApexBio 100 mg
EUR 154
Description: Paroxetine Hydrochloride is a antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs).Paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake. Paroxetine likely inhibits the reuptake of serotonin at the

Paroxetine HCl

B2252-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 108
Description: Paroxetine Hydrochloride is a antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs).Paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake. Paroxetine likely inhibits the reuptake of serotonin at the

Paroxetine HCl

B2252-S ApexBio Evaluation Sample
EUR 81
Description: Paroxetine Hydrochloride is a antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs).Paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake. Paroxetine likely inhibits the reuptake of serotonin at the

SB269970 HCl

B2254-10 ApexBio 10 mg
EUR 248
Description: SB269970 HCl is a potent and selective antagonist of 5-HT7 receptor with pKi value of 8.3 [1].SB269970 is a selective antagonist of 5-HT7 receptor. It shows at least 100-fold selective against 5-HT7 over a variety of receptors and enzymes

SB269970 HCl

B2254-25 ApexBio 25 mg
EUR 493
Description: SB269970 HCl is a potent and selective antagonist of 5-HT7 receptor with pKi value of 8.3 [1].SB269970 is a selective antagonist of 5-HT7 receptor. It shows at least 100-fold selective against 5-HT7 over a variety of receptors and enzymes

SB269970 HCl

B2254-5 ApexBio 5 mg
EUR 154
Description: SB269970 HCl is a potent and selective antagonist of 5-HT7 receptor with pKi value of 8.3 [1].SB269970 is a selective antagonist of 5-HT7 receptor. It shows at least 100-fold selective against 5-HT7 over a variety of receptors and enzymes

SB269970 HCl

B2254-50 ApexBio 50 mg
EUR 833
Description: SB269970 HCl is a potent and selective antagonist of 5-HT7 receptor with pKi value of 8.3 [1].SB269970 is a selective antagonist of 5-HT7 receptor. It shows at least 100-fold selective against 5-HT7 over a variety of receptors and enzymes

Sertraline HCl

B2257-10 ApexBio 10 mg
EUR 108
Description: Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.

Sertraline HCl

B2257-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 108
Description: Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.

Sertraline HCl

B2257-50 ApexBio 50 mg
EUR 270
Description: Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.

Dapoxetine HCl

B2264-100 ApexBio 100 mg
EUR 224
Description: Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor(SSRI).Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (

Dapoxetine HCl

B2264-25 ApexBio 25 mg
EUR 108
Description: Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor(SSRI).Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (

Dapoxetine HCl

B2264-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 125
Description: Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor(SSRI).Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (

Dapoxetine HCl

B2264-50 ApexBio 50 mg
EUR 148
Description: Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor(SSRI).Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (

Dapoxetine HCl

B2264-S ApexBio Evaluation Sample
EUR 81
Description: Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor(SSRI).Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (

Ambroxol HCl

B2267-50 ApexBio 50 mg
EUR 108
Description: AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 ?M and 22.5 ?M for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 ?M. Phase 3.

Ambroxol HCl

B2267-S ApexBio Evaluation Sample
EUR 81
Description: AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 ?M and 22.5 ?M for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 ?M. Phase 3.

Procaine HCl

B2273-50 ApexBio 50 mg
EUR 128
Description: Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 ?M, 0.296 mM and 45.5 ?M, which is also an inhibitor of 5-HT3 with KD of 1.7 ?M.

Procaine HCl

B2273-S ApexBio Evaluation Sample
EUR 81
Description: Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 ?M, 0.296 mM and 45.5 ?M, which is also an inhibitor of 5-HT3 with KD of 1.7 ?M.

Proparacaine HCl

B2274-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 108
Description: Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.

Proparacaine HCl

B2274-50 ApexBio 50 mg
EUR 128
Description: Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.

Proparacaine HCl

B2274-S ApexBio Evaluation Sample
EUR 81
Description: Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.

Propafenone HCl

B2281-10 ApexBio 10 mg
EUR 277
Description: Propafenone Hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.

Propafenone HCl

B2281-25 ApexBio 25 mg
EUR 440
Description: Propafenone Hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.

Propafenone HCl

B2281-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 189
Description: Propafenone Hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.

Propafenone HCl

B2281-50 ApexBio 50 mg
EUR 683
Description: Propafenone Hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.

Propafenone HCl

B2281-S ApexBio Evaluation Sample
EUR 81
Description: Propafenone Hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.

Daunorubicin HCl

B2285-10 ApexBio 10 mg
EUR 108
Description: Daunorubicin HCl is an inhibitor of DNA topoisomerase II [1].Daunorubicin is an anthracycline antibiotic. It is also used as an effective chemotherapeutic agent against tumors especially acute myeloid leukaemia and acute lymphocytic leukaemia.

Daunorubicin HCl

B2285-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 108
Description: Daunorubicin HCl is an inhibitor of DNA topoisomerase II [1].Daunorubicin is an anthracycline antibiotic. It is also used as an effective chemotherapeutic agent against tumors especially acute myeloid leukaemia and acute lymphocytic leukaemia.

Daunorubicin HCl

B2285-50 ApexBio 50 mg
EUR 224
Description: Daunorubicin HCl is an inhibitor of DNA topoisomerase II [1].Daunorubicin is an anthracycline antibiotic. It is also used as an effective chemotherapeutic agent against tumors especially acute myeloid leukaemia and acute lymphocytic leukaemia.

Topotecan HCl

B2296-10 ApexBio 10 mg
EUR 96
Description: Topotecan HCl?SKF104864?is an inhibitor of topoisomerase 1 and semisynthetic analogue of camptothecin [1].Topotecan HCl?SKF104864?has been reported to have a potent antitumor activity against tumors in murine models.

Topotecan HCl

B2296-100 ApexBio 100 mg
EUR 224
Description: Topotecan HCl?SKF104864?is an inhibitor of topoisomerase 1 and semisynthetic analogue of camptothecin [1].Topotecan HCl?SKF104864?has been reported to have a potent antitumor activity against tumors in murine models.

Topotecan HCl

B2296-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 113
Description: Topotecan HCl?SKF104864?is an inhibitor of topoisomerase 1 and semisynthetic analogue of camptothecin [1].Topotecan HCl?SKF104864?has been reported to have a potent antitumor activity against tumors in murine models.

Topotecan HCl

B2296-50 ApexBio 50 mg
EUR 200
Description: Topotecan HCl?SKF104864?is an inhibitor of topoisomerase 1 and semisynthetic analogue of camptothecin [1].Topotecan HCl?SKF104864?has been reported to have a potent antitumor activity against tumors in murine models.

Tetrahydropapaverine HCl

B3670-10 ApexBio 10 mg
EUR 495

Tetrahydropapaverine HCl

B3670-5.1 ApexBio 10 mM (in 1mL DMSO)
EUR 683

Moreover, a number of different compounds are recognized (e.g., ethanol) that correlate with inhabitants density and originate from a number of VCP sources. Ethanol and fragrances are amongst the most considerable and reactive VOCs related to VCP emissions.

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May 2022
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