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Metabolome analysis and chemical profiling of Indonesian royal jellies as the raw material for cosmetic and bio-supplement products

Metabolome analysis and chemical profiling of Indonesian royal jellies as the raw material for cosmetic and bio-supplement products

Posted on September 11, 2021October 7, 2021 by Lindsey

Royal jellies (RJs) possess moisturizing, emulsifying, and stabilizing properties, and a number of pharmacological actions have additionally been discovered to be current, which make them a perfect element for cosmetic and skincare products. Nevertheless, regardless of the considerable efficacies, there’s a lack of research that discover the chemical composition of RJ utilizing metabolome analysis.

Moreover, an analysis of the chemical composition of Indonesian RJs collected from completely different areas has but to be carried out. Due to this fact, the fundamental goal of this examine was to determine any variations in the chemical composition of such RJs. Chemical profiling was additionally carried out to allow extra focused utilization primarily based on the precise compositions.

Chemical profiling can be essential given the wealthy Indonesian biodiversity and the excessive dependence of the RJ compositions on the botanical supply. On this analysis, ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used as half of an untargeted metabolomics method.

From the chemical profiling, >30 compounds have been recognized throughout 4 RJ samples. The key constituents of the samples have been discovered to be oligosaccharides, fatty acids, and adenosine monophosphate derivatives. In the meantime, sucrose and planteose have been discovered to be highest in the samples from Banjarnegara and Kediri, whereas dimethyloctanoic acid was discovered to be distinctive to the pattern from Banjarnegara.

It was additionally found that the RJs from Demak and Tuban contained extra natural fatty acids and oligosaccharides than the different samples. Though the pattern from Demak demonstrated good potential for use in the cosmetic, skincare, and bio-supplement industries, the larger abundance of fatty acids and oligosaccharides in the pattern from Tuban indicated that it’s maybe the best suited RJ for use on this discipline.

Information Mining Approaches for Assessing Chemical Coexposures Utilizing Shopper Product Buy Information

The use of shopper products presents a possible for chemical exposures to people. Toxicity testing and publicity fashions are routinely employed to estimate dangers from their use; nevertheless, a key problem is the sparseness of info regarding who makes use of products and which products are used contemporaneously.

Our objective was to display a way to deduce use patterns by method of buy knowledge. We examined buy patterns for three varieties of private care products (cosmetics, hair care, and skincare) and two family care products (family cleaners and laundry provides) utilizing knowledge from 60,000 households collected over a one-year interval in 2012.

The market basket analysis methodology frequent itemset mining (FIM) was used to determine co-occurring units of product purchases for all households and demographic teams primarily based on revenue, training, race/ethnicity, and household composition. Our methodology captured strong co-occurrence patterns for private and family products, globally and for completely different demographic teams.

FIM recognized cosmetic co-occurrence patterns captured in prior surveys of cosmetic use, as properly as a pattern of elevated variety of cosmetic purchases as youngsters mature to teenage years. We suggest that shopper product buy knowledge may be mined to tell person-oriented use patterns for high-throughput chemical screening purposes, for mixture and mixed chemical danger evaluations.

Chemical Elimination of Lead Corrosion Products

Restoration therapy, specimen preparation or mass loss measurements on coupons made of lead require a dependable course of of dissolution of corrosion products. On this examine, a number of varieties of mannequin corrosion products with compositions consultant of these discovered on actual objects have been ready and characterised.

Ten options have been then totally examined in interval cleansing experiments, relating to the effectivity of removing of the corrosion products, corrosivity in the direction of naked lead, and remnants left on the floor. The answer advisable in the present model of the ISO 8470 customary was discovered to be improper for the cleansing of each historic artefacts and corrosion coupons attributable to its incapability to take away sulfide corrosion products and the danger of floor contamination and staining.

An answer of 20% hydrochloric acid is the best option for the preparation of lead coupons earlier than publicity or for analysis of mass loss of uncovered samples as a result of its considerably larger corrosivity in the direction of metallic lead is tolerable for these purposes.

Metabolome analysis and chemical profiling of AGTC bioproducts with electrophoresis
Accugel gel electrophoresis

Rochelle salt answer was discovered to be optimum for the cleansing of historic artefacts free of sulfide corrosion products attributable to the lowest corrosivity. None of these various options depart remnants on the floor and they’re environment friendly at laboratory temperature.

Figuring out Risky Chemical Product Tracer Compounds in U.S. Cities

With visitors emissions of risky natural compounds (VOCs) reducing quickly over the final a long time, the contributions of the emissions from different supply classes, such as risky chemical products (VCPs), have turn out to be extra obvious in city air. On this work, in situ measurements of numerous VOCs are reported for New York Metropolis, Pittsburgh, Chicago, and Denver.

The magnitude of completely different emission sources relative to visitors is set by measuring the city enhancement of particular person compounds relative to the enhancement of benzene, a recognized tracer of fossil gas in the United States. The enhancement ratios of a number of VCP compounds to benzene correlate properly with inhabitants density (R2 ∼ 0.6-0.8).

These observations are in keeping with the expectation that some human exercise ought to correlate higher with the inhabitants density than transportation emissions, attributable to the decrease per capita fee of driving in denser cities. Utilizing these knowledge, along with a bottom-up fuel-based stock of car emissions and risky chemical products (FIVE-VCP) stock, we determine tracer compounds for completely different VCP classes: decamethylcyclopentasiloxane (D5-siloxane) for private care products, monoterpenes for fragrances, p-dichlorobenzene for pesticides, D4-siloxane for adhesives, para-chlorobenzotrifluoride (PCBTF) for solvent-based coatings, and Texanol for water-based coatings.

Gemcitabine HCl

A1402-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Gemcitabine HCl is an inhibitor of DNA synthesis with the IC50 value of 240.4±29.0 ?M (CCRF-CEM/dCK-/- cells), 14.7±2.8 nM (TC-1 cells), 36.7 ± 5.1 ?M (TC-1-GR cells), and 50 nM (PANC1 cells).

Fluoxetine HCl

A2436-100 ApexBio 100 mg 177.6 EUR
Description: Fluoxetine is a specific presynaptic serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.The serotonin receptor, also known as 5-HT receptor, is a member of G protein-coupled receptorfound in the central and peripheral nervous systems.

Fluoxetine HCl

A2436-5.1 ApexBio 10 mM (in 1mL DMSO) 170.4 EUR
Description: Fluoxetine is a specific presynaptic serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.The serotonin receptor, also known as 5-HT receptor, is a member of G protein-coupled receptorfound in the central and peripheral nervous systems.

Fluoxetine HCl

A2436-500 ApexBio 500 mg 393.6 EUR
Description: Fluoxetine is a specific presynaptic serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.The serotonin receptor, also known as 5-HT receptor, is a member of G protein-coupled receptorfound in the central and peripheral nervous systems.

Epirubicin HCl

A2451-100 ApexBio 100 mg 560.4 EUR
Description: Epirubicin is an inhibitor of DNA topoisomerase (TOPII) [1].Epirubicin belongs to the Anthracylines chemical class, it is a sort of DNA topoisomerase poison.

Epirubicin HCl

A2451-25 ApexBio 25 mg 309.6 EUR
Description: Epirubicin is an inhibitor of DNA topoisomerase (TOPII) [1].Epirubicin belongs to the Anthracylines chemical class, it is a sort of DNA topoisomerase poison.

Epirubicin HCl

A2451-5 ApexBio 5 mg 122.4 EUR
Description: Epirubicin is an inhibitor of DNA topoisomerase (TOPII) [1].Epirubicin belongs to the Anthracylines chemical class, it is a sort of DNA topoisomerase poison.

Epirubicin HCl

A2451-5.1 ApexBio 10 mM (in 1mL DMSO) 147.6 EUR
Description: Epirubicin is an inhibitor of DNA topoisomerase (TOPII) [1].Epirubicin belongs to the Anthracylines chemical class, it is a sort of DNA topoisomerase poison.

Idarubicin HCl

A2476-100 ApexBio 100 mg 686.4 EUR
Description: Idarubicin is an inhibitor of DNA topoisomerase II [1].Idarubicin is a synthetic anthracycline anticancer drug widely used in the treatment of acute myelogenous leukemia and some other hematological malignancies.

Idarubicin HCl

A2476-25 ApexBio 25 mg 268.8 EUR
Description: Idarubicin is an inhibitor of DNA topoisomerase II [1].Idarubicin is a synthetic anthracycline anticancer drug widely used in the treatment of acute myelogenous leukemia and some other hematological malignancies.

Idarubicin HCl

A2476-5 ApexBio 5 mg 129.6 EUR
Description: Idarubicin is an inhibitor of DNA topoisomerase II [1].Idarubicin is a synthetic anthracycline anticancer drug widely used in the treatment of acute myelogenous leukemia and some other hematological malignancies.

Idarubicin HCl

A2476-5.1 ApexBio 10 mM (in 1mL DMSO) 170.4 EUR
Description: Idarubicin is an inhibitor of DNA topoisomerase II [1].Idarubicin is a synthetic anthracycline anticancer drug widely used in the treatment of acute myelogenous leukemia and some other hematological malignancies.

ADL5859 HCl

A2986-100 ApexBio 100 mg 1423.2 EUR
Description: Selective ? opioid receptor agonists are promising potential therapeutic agents for the treatment of various types of pain conditions. A spirocyclic derivative was identified as a promising hit through screening.

ADL5859 HCl

A2986-25 ApexBio 25 mg 588 EUR
Description: Selective ? opioid receptor agonists are promising potential therapeutic agents for the treatment of various types of pain conditions. A spirocyclic derivative was identified as a promising hit through screening.

ADL5859 HCl

A2986-5 ApexBio 5 mg 226.8 EUR
Description: Selective ? opioid receptor agonists are promising potential therapeutic agents for the treatment of various types of pain conditions. A spirocyclic derivative was identified as a promising hit through screening.

ADL5859 HCl

A2986-5.1 ApexBio 10 mM (in 1mL DMSO) 261.6 EUR
Description: Selective ? opioid receptor agonists are promising potential therapeutic agents for the treatment of various types of pain conditions. A spirocyclic derivative was identified as a promising hit through screening.

Prazosin HCl

A5318-100 ApexBio 100 mg 199.2 EUR
Description: ?1 and ?2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). Also available as part of the ?1-Adrenoceptor Tocriset? and Mixed Adre

Prazosin HCl

A5318-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: ?1 and ?2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). Also available as part of the ?1-Adrenoceptor Tocriset? and Mixed Adre

Moxifloxacin HCl

A5323-200 ApexBio 200 mg 268.8 EUR
Description: Moxifloxacin HCl is anti-infective compound with a broad antibacterial spectrum.[1] Moxifloxacin is a fourth generation fluoroquinolone antibacterial agent with a broad antibacterial spectrum against Gram positive bacteria and Gram negative bacteria in vitro.

Moxifloxacin HCl

A5323-5.1 ApexBio 10 mM (in 1mL DMSO) 135.6 EUR
Description: Moxifloxacin HCl is anti-infective compound with a broad antibacterial spectrum.[1] Moxifloxacin is a fourth generation fluoroquinolone antibacterial agent with a broad antibacterial spectrum against Gram positive bacteria and Gram negative bacteria in vitro.

Moxifloxacin HCl

A5323-50 ApexBio 50 mg 129.6 EUR
Description: Moxifloxacin HCl is anti-infective compound with a broad antibacterial spectrum.[1] Moxifloxacin is a fourth generation fluoroquinolone antibacterial agent with a broad antibacterial spectrum against Gram positive bacteria and Gram negative bacteria in vitro.

Ziprasidone HCl

A5350-100 ApexBio 100 mg 199.2 EUR
Description: Atypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT2A receptors with a 5-HT2A/D2 affinity ratio greater than any other clinically available atypical antipsychotics (pKi values are 9.38,

Ziprasidone HCl

A5350-5.1 ApexBio 10 mM (in 1mL DMSO) 142.8 EUR
Description: Atypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT2A receptors with a 5-HT2A/D2 affinity ratio greater than any other clinically available atypical antipsychotics (pKi values are 9.38,

SRT1720 HCl

A4180-10 ApexBio 10 mg 309.6 EUR
Description: SRT1720 is a small-molecule compound which has the ability of activating the sirtuin subtype SIRT1 in vitro. The activity of SRT1720 as a SIRT1 activator is stronger than that of resveratrol.

SRT1720 HCl

A4180-200 ApexBio 200 mg 1730.4 EUR
Description: SRT1720 is a small-molecule compound which has the ability of activating the sirtuin subtype SIRT1 in vitro. The activity of SRT1720 as a SIRT1 activator is stronger than that of resveratrol.

SRT1720 HCl

A4180-5 ApexBio 5 mg 212.4 EUR
Description: SRT1720 is a small-molecule compound which has the ability of activating the sirtuin subtype SIRT1 in vitro. The activity of SRT1720 as a SIRT1 activator is stronger than that of resveratrol.

SRT1720 HCl

A4180-5.1 ApexBio 10 mM (in 1mL DMSO) 226.8 EUR
Description: SRT1720 is a small-molecule compound which has the ability of activating the sirtuin subtype SIRT1 in vitro. The activity of SRT1720 as a SIRT1 activator is stronger than that of resveratrol.

SRT1720 HCl

A4180-50 ApexBio 50 mg 825.6 EUR
Description: SRT1720 is a small-molecule compound which has the ability of activating the sirtuin subtype SIRT1 in vitro. The activity of SRT1720 as a SIRT1 activator is stronger than that of resveratrol.

SRT1720 HCl

A4180-S ApexBio Evaluation Sample 97.2 EUR
Description: SRT1720 is a small-molecule compound which has the ability of activating the sirtuin subtype SIRT1 in vitro. The activity of SRT1720 as a SIRT1 activator is stronger than that of resveratrol.

Rosiglitazone HCl

A4310-100 ApexBio 100 mg 157.2 EUR
Description: Rosiglitazone is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.

Rosiglitazone HCl

A4310-200 ApexBio 200 mg 212.4 EUR
Description: Rosiglitazone is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.

Rosiglitazone HCl

A4310-25 ApexBio 25 mg 129.6 EUR
Description: Rosiglitazone is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.

Pioglitazone HCl

A4324-10 ApexBio 10 mg 142.8 EUR
Description: Pioglitazone HCl is a potent and highly selective agonist of PPAR? with IC50 value of 3?M[1].Pioglitazone HCl can increase both insulin-stimulated glucose uptake in peripheral tissues and insulin sensitivity in hepatic and adipose tissue.

Pioglitazone HCl

A4324-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Pioglitazone HCl is a potent and highly selective agonist of PPAR? with IC50 value of 3?M[1].Pioglitazone HCl can increase both insulin-stimulated glucose uptake in peripheral tissues and insulin sensitivity in hepatic and adipose tissue.

Pioglitazone HCl

A4324-50 ApexBio 50 mg 199.2 EUR
Description: Pioglitazone HCl is a potent and highly selective agonist of PPAR? with IC50 value of 3?M[1].Pioglitazone HCl can increase both insulin-stimulated glucose uptake in peripheral tissues and insulin sensitivity in hepatic and adipose tissue.

Anagrelide HCl

A4352-10 ApexBio 10 mg 122.4 EUR
Description: Anagrelide is a selective thrombocytopenic agent [1].Anagrelide is a FDA-approved drug for the treatment of essential thrombocythemia. It is originally identified as a potential inhibitor of platelet aggregation.

Anagrelide HCl

A4352-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Anagrelide is a selective thrombocytopenic agent [1].Anagrelide is a FDA-approved drug for the treatment of essential thrombocythemia. It is originally identified as a potential inhibitor of platelet aggregation.

Anagrelide HCl

A4352-50 ApexBio 50 mg 282 EUR
Description: Anagrelide is a selective thrombocytopenic agent [1].Anagrelide is a FDA-approved drug for the treatment of essential thrombocythemia. It is originally identified as a potential inhibitor of platelet aggregation.

Dorzolamide HCl

A4357-10 ApexBio 10 mg 153.6 EUR
Description: Dorzolamide HCl is a carbonic anhydrase inhibitor.

Dorzolamide HCl

A4357-100 ApexBio 100 mg 522 EUR
Description: Dorzolamide HCl is a carbonic anhydrase inhibitor.

Dorzolamide HCl

A4357-25 ApexBio 25 mg 205.2 EUR
Description: Dorzolamide HCl is a carbonic anhydrase inhibitor.

Dorzolamide HCl

A4357-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Dorzolamide HCl is a carbonic anhydrase inhibitor.

Dorzolamide HCl

A4357-50 ApexBio 50 mg 338.4 EUR
Description: Dorzolamide HCl is a carbonic anhydrase inhibitor.

Tetracyclin Hcl

abx082256-5g Abbexa 5 g 226.8 EUR

Guanidine Hcl

abx082517-500g Abbexa 500 g 226.8 EUR

Tris-Hcl

20-abx082568 Abbexa
  • 226.80 EUR
  • 276.00 EUR
  • 100 g
  • 500 g

Tetracyclin Hcl

abx082590-5g Abbexa 5 g 210 EUR

EDC-HCl

20-abx095087 Abbexa
  • 610.80 EUR
  • 444.00 EUR
  • 1 kg
  • 500 g

Verapamil HCl

20-abx076503 Abbexa
  • 260.40 EUR
  • 360.00 EUR
  • 1 g
  • 5 g

Duloxetine HCl

20-abx076532 Abbexa
  • 292.80 EUR
  • 543.60 EUR
  • 10 mg
  • 50 mg

Puromycin HCl

20-abx076662 Abbexa
  • 526.80 EUR
  • 276.00 EUR
  • 250 mg
  • 50 mg

Nicardipine HCl

20-abx076668 Abbexa
  • 360.00 EUR
  • 276.00 EUR
  • 250 mg
  • 50 mg

Ambroxol HCl

20-abx076696 Abbexa
  • 376.80 EUR
  • 309.60 EUR
  • 500 mg
  • 50 mg

Irinotecan HCl

20-abx076771 Abbexa
  • 861.60 EUR
  • 376.80 EUR
  • 250 mg
  • 50 mg

Thioridazine HCl

A8537-1000 ApexBio 1 g 226.8 EUR
Description: Thioridazine·HCl is a calcium channel protein inhibitor as well as D2DR/D4DR inhibitor. Its administration has been associated with hypotension. It has also been, after chronic treatment, used to test increased sensitivity of dopaminergic agents.

Thioridazine HCl

A8537-5 ApexBio 5 mg 129.6 EUR
Description: Thioridazine·HCl is a calcium channel protein inhibitor as well as D2DR/D4DR inhibitor. Its administration has been associated with hypotension. It has also been, after chronic treatment, used to test increased sensitivity of dopaminergic agents.

Thioridazine HCl

A8537-5.1 ApexBio 10 mM (in 1mL DMSO) 135.6 EUR
Description: Thioridazine·HCl is a calcium channel protein inhibitor as well as D2DR/D4DR inhibitor. Its administration has been associated with hypotension. It has also been, after chronic treatment, used to test increased sensitivity of dopaminergic agents.

Ondansetron HCl

A5166-10 ApexBio 10 mg 129.6 EUR
Description: Ondansetron hydrochloride dihydrate is a serotonin-3 (5-HT3) receptor antagonist.

Ondansetron HCl

A5166-5.1 ApexBio 10 mM (in 1mL DMSO) 157.2 EUR
Description: Ondansetron hydrochloride dihydrate is a serotonin-3 (5-HT3) receptor antagonist.

Ondansetron HCl

A5166-50 ApexBio 50 mg 177.6 EUR
Description: Ondansetron hydrochloride dihydrate is a serotonin-3 (5-HT3) receptor antagonist.

Alfuzosin HCl

A5173-100 ApexBio 100 mg 477.6 EUR
Description: Functionally uro-selective ?1 adrenoceptor antagonist that does not discriminate between ?1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascula

Alfuzosin HCl

A5173-25 ApexBio 25 mg 199.2 EUR
Description: Functionally uro-selective ?1 adrenoceptor antagonist that does not discriminate between ?1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascula

Alfuzosin HCl

A5173-5 ApexBio 5 mg 129.6 EUR
Description: Functionally uro-selective ?1 adrenoceptor antagonist that does not discriminate between ?1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascula

Alfuzosin HCl

A5173-5.1 ApexBio 10 mM (in 1mL DMSO) 186 EUR
Description: Functionally uro-selective ?1 adrenoceptor antagonist that does not discriminate between ?1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascula

Arbidol HCl

A8362-10 ApexBio 10 mg 129.6 EUR
Description: Arbidol (Umifenovir) hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane.

Arbidol HCl

A8362-100 ApexBio 100 mg 421.2 EUR
Description: Arbidol (Umifenovir) hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane.

Arbidol HCl

A8362-5.1 ApexBio 10 mM (in 1mL DMSO) 135.6 EUR
Description: Arbidol (Umifenovir) hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane.

Conivaptan HCl

A8402-10 ApexBio 10 mg 166.8 EUR
Description: Conivaptan Hydrochloride is a non-peptide inhibitor of antidiuretic hormone. Conivaptan Hydrochloride is used for treatment of congestive heart failure.

Conivaptan HCl

A8402-100 ApexBio 100 mg 808.8 EUR
Description: Conivaptan Hydrochloride is a non-peptide inhibitor of antidiuretic hormone. Conivaptan Hydrochloride is used for treatment of congestive heart failure.

Conivaptan HCl

A8402-5.1 ApexBio 10 mM (in 1mL DMSO) 181.2 EUR
Description: Conivaptan Hydrochloride is a non-peptide inhibitor of antidiuretic hormone. Conivaptan Hydrochloride is used for treatment of congestive heart failure.

Dicyclomine HCl

A8409-1000 ApexBio 1 g 517.2 EUR
Description: Used as a gastrointestinal antispasmodic antacid.

Dicyclomine HCl

A8409-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Used as a gastrointestinal antispasmodic antacid.

Dicyclomine HCl

A8409-5000 ApexBio 5 g 1198.8 EUR
Description: Used as a gastrointestinal antispasmodic antacid.

Difloxacin HCl

A8411-1000 ApexBio 1 g 142.8 EUR
Description: Difloxacin HCl is a quinolone antimicrobial antibiotic [1]. Quinolone antibiotics target bacterial DNA gyrase which is required during DNA replication, subsequent DNA synthesis and ultimately cell division.

Difloxacin HCl

A8411-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Difloxacin HCl is a quinolone antimicrobial antibiotic [1]. Quinolone antibiotics target bacterial DNA gyrase which is required during DNA replication, subsequent DNA synthesis and ultimately cell division.

Difloxacin HCl

A8411-5000 ApexBio 5 g 301.2 EUR
Description: Difloxacin HCl is a quinolone antimicrobial antibiotic [1]. Quinolone antibiotics target bacterial DNA gyrase which is required during DNA replication, subsequent DNA synthesis and ultimately cell division.

Diperodon HCl

A8413-100 ApexBio 100 mg 129.6 EUR
Description: Diperodon HCl

Diperodon HCl

A8413-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Diperodon HCl

Diphenylpyraline HCl

A8415-1000 ApexBio 1 g 517.2 EUR
Description: Diphenylpyraline is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class.

Diphenylpyraline HCl

A8415-10000 ApexBio 10 g 1783.2 EUR
Description: Diphenylpyraline is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class.

Diphenylpyraline HCl

A8415-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Diphenylpyraline is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class.

Diphenylpyraline HCl

A8415-5000 ApexBio 5 g 1198.8 EUR
Description: Diphenylpyraline is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class.

Doxapram HCl

A8419-5.1 ApexBio 10 mM (in 1mL DMSO) 170.4 EUR
Description: Doxapram HCl is a respiratory stimulant.

Doxapram HCl

A8419-50 ApexBio 50 mg 157.2 EUR
Description: Doxapram HCl is a respiratory stimulant.

Doxycycline HCl

A8420-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Doxycycline Hydrochloride is a synthetic tetracycline derivative with similar antimicrobial activity.Doxycycline is a tetracycline antibiotic which is commonly used to treat a variety of infections. Doxycycline treatment resulted in a 96% loss of Wolbachi

Doxycycline HCl

A8420-50 ApexBio 50 mg 157.2 EUR
Description: Doxycycline Hydrochloride is a synthetic tetracycline derivative with similar antimicrobial activity.Doxycycline is a tetracycline antibiotic which is commonly used to treat a variety of infections. Doxycycline treatment resulted in a 96% loss of Wolbachi

Duloxetine HCl

A8421-10 ApexBio 10 mg 166.8 EUR
Description: Duloxetine HCl is a selective serotonin and norepinephrine reuptake inhibitor .

Duloxetine HCl

A8421-100 ApexBio 100 mg 808.8 EUR
Description: Duloxetine HCl is a selective serotonin and norepinephrine reuptake inhibitor .

Duloxetine HCl

A8421-5.1 ApexBio 10 mM (in 1mL DMSO) 135.6 EUR
Description: Duloxetine HCl is a selective serotonin and norepinephrine reuptake inhibitor .

Ethambutol HCl

A8427-5.1 ApexBio 10 mM (in 1mL DMSO) 135.6 EUR
Description: Nocodazole is a tubulin production inhibitor, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 value of 0.21 ?M, 0.53 ?M and 0.64 ?M, respectively [1].Nocodazole is an inhibitor of microtubule polymerization which inhibits insulin-stimulated glucose transport.

Ethambutol HCl

A8427-50 ApexBio 50 mg 157.2 EUR
Description: Nocodazole is a tubulin production inhibitor, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 value of 0.21 ?M, 0.53 ?M and 0.64 ?M, respectively [1].Nocodazole is an inhibitor of microtubule polymerization which inhibits insulin-stimulated glucose transport.

GW3965 HCl

A8444-10 ApexBio 10 mg 205.2 EUR
Description: GW3965 HCl is a selective, orally active non-steroidal agonist for the liver X receptor (LXR) [1].Nuclear receptors LXR? and LXR? have an important role in control of cholesterol and fatty acid metabolism in multiple cell types.

GW3965 HCl

A8444-5 ApexBio 5 mg 154.8 EUR
Description: GW3965 HCl is a selective, orally active non-steroidal agonist for the liver X receptor (LXR) [1].Nuclear receptors LXR? and LXR? have an important role in control of cholesterol and fatty acid metabolism in multiple cell types.

GW3965 HCl

A8444-5.1 ApexBio 10 mM (in 1mL DMSO) 199.2 EUR
Description: GW3965 HCl is a selective, orally active non-steroidal agonist for the liver X receptor (LXR) [1].Nuclear receptors LXR? and LXR? have an important role in control of cholesterol and fatty acid metabolism in multiple cell types.

GW3965 HCl

A8444-50 ApexBio 50 mg 614.4 EUR
Description: GW3965 HCl is a selective, orally active non-steroidal agonist for the liver X receptor (LXR) [1].Nuclear receptors LXR? and LXR? have an important role in control of cholesterol and fatty acid metabolism in multiple cell types.

Imidapril HCl

A8447-10 ApexBio 10 mg 129.6 EUR
Description: Imidapril (INN) is an ACE inhibitor used as an antihypertensive drug and for the treatment of chronic heart failure.

Imidapril HCl

A8447-5.1 ApexBio 10 mM (in 1mL DMSO) 151.2 EUR
Description: Imidapril (INN) is an ACE inhibitor used as an antihypertensive drug and for the treatment of chronic heart failure.

Imidapril HCl

A8447-50 ApexBio 50 mg 274.8 EUR
Description: Imidapril (INN) is an ACE inhibitor used as an antihypertensive drug and for the treatment of chronic heart failure.

Noscapine HCl

A8479-1000 ApexBio 1 g 517.2 EUR
Description: Noscapine hydrochloride is the hydrochloride form of Noscapine. Noscapine is an opioid alkaloid with several actions. Antagonist at Bradykinin B Receptor (bradykinin receptors) , inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues.

Noscapine HCl

A8479-10000 ApexBio 10 g 1783.2 EUR
Description: Noscapine hydrochloride is the hydrochloride form of Noscapine. Noscapine is an opioid alkaloid with several actions. Antagonist at Bradykinin B Receptor (bradykinin receptors) , inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues.

Noscapine HCl

A8479-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Noscapine hydrochloride is the hydrochloride form of Noscapine. Noscapine is an opioid alkaloid with several actions. Antagonist at Bradykinin B Receptor (bradykinin receptors) , inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues.

Noscapine HCl

A8479-5000 ApexBio 5 g 1198.8 EUR
Description: Noscapine hydrochloride is the hydrochloride form of Noscapine. Noscapine is an opioid alkaloid with several actions. Antagonist at Bradykinin B Receptor (bradykinin receptors) , inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues.

Mianserin HCl

A1796-100 ApexBio 100 mg 338.4 EUR
Description: Non-selective 5-HT2 receptor antagonist. Has moderate affinity for 5-HT6. Antidepressant.

Mianserin HCl

A1796-5 ApexBio 5 mg 129.6 EUR
Description: Non-selective 5-HT2 receptor antagonist. Has moderate affinity for 5-HT6. Antidepressant.

Mianserin HCl

A1796-5.1 ApexBio 10 mM (in 1mL DMSO) 151.2 EUR
Description: Non-selective 5-HT2 receptor antagonist. Has moderate affinity for 5-HT6. Antidepressant.

Bendamustine HCl

A1984-10 ApexBio 10 mg 199.2 EUR
Description: Bendamustine HCl is an alkylating agent associated with DNA damage with IC50 of 50 ?M [1]. It has been reported that bendamustine is activated under DNA damage stress and apoptosis.

Bendamustine HCl

A1984-5 ApexBio 5 mg 129.6 EUR
Description: Bendamustine HCl is an alkylating agent associated with DNA damage with IC50 of 50 ?M [1]. It has been reported that bendamustine is activated under DNA damage stress and apoptosis.

Bendamustine HCl

A1984-5.1 ApexBio 10 mM (in 1mL DMSO) 184.8 EUR
Description: Bendamustine HCl is an alkylating agent associated with DNA damage with IC50 of 50 ?M [1]. It has been reported that bendamustine is activated under DNA damage stress and apoptosis.

Cyclobenzaprine HCl

20-abx180713 Abbexa
  • 292.80 EUR
  • 393.60 EUR
  • 944.40 EUR
  • 100 mg
  • 1 g
  • 5 g

Tamsulosin HCl

20-abx180875 Abbexa
  • 477.60 EUR
  • 760.80 EUR
  • 100 mg
  • 250 mg

Decloxizini HCl

20-abx181258 Abbexa
  • 343.20 EUR
  • 1045.20 EUR
  • 477.60 EUR
  • 100 mg
  • 1 g
  • 250 mg

Meclofenoxate HCl

abx181309-100g Abbexa 100 g 427.2 EUR

Cyclopentanemethylamine HCl

20-abx182408 Abbexa
  • 543.60 EUR
  • 3316.80 EUR
  • 1245.60 EUR
  • 1 g
  • 25 g
  • 5 g

Antazoline HCl

abx183853-25g Abbexa 25 g 343.2 EUR

Benzydamine HCl

abx183874-10g Abbexa 10 g 493.2 EUR

Ciprofloxacin HCl

20-abx183943 Abbexa
  • 594.00 EUR
  • 226.80 EUR
  • 326.40 EUR
  • 243.60 EUR
  • 100 g
  • 1 g
  • 25 g
  • 5 g

Doxepin HCl

20-abx184015 Abbexa
  • 1328.40 EUR
  • 243.60 EUR
  • 610.80 EUR
  • 343.20 EUR
  • 100 g
  • 1 g
  • 25 g
  • 5 g

Doxorubicin HCl

20-abx184016 Abbexa
  • 895.20 EUR
  • 1779.60 EUR
  • 1 g
  • 5 g

Doxycycline HCl

20-abx184017 Abbexa
  • 811.20 EUR
  • 410.40 EUR
  • 100 g
  • 25 g

Isoprenaline HCl

20-abx184138 Abbexa
  • 260.40 EUR
  • 828.00 EUR
  • 376.80 EUR
  • 1 g
  • 25 g
  • 5 g

Octopamine HCl

20-abx184289 Abbexa
  • 376.80 EUR
  • 243.60 EUR
  • 577.20 EUR
  • 309.60 EUR
  • 10 g
  • 1 g
  • 25 g
  • 5 g

Pd128907 Hcl

20-abx184299 Abbexa
  • 543.60 EUR
  • 393.60 EUR
  • 10 mg
  • 5 mg

Propranolol HCl

abx184325-1g Abbexa 1 g 226.8 EUR

Terbinafine HCl

20-abx184395 Abbexa
  • 343.20 EUR
  • 210.00 EUR
  • 243.60 EUR
  • 100 g
  • 1 g
  • 25 g

Atomoxetine HCl

20-abx184648 Abbexa
  • 393.60 EUR
  • 760.80 EUR
  • 1 g
  • 5 g

Procaine HCl

20-abx184762 Abbexa
  • 292.80 EUR
  • 577.20 EUR
  • 100 g
  • 500 g

Thiamine HCl

20-abx184786 Abbexa
  • 292.80 EUR
  • 526.80 EUR
  • 100 g
  • 500 g

Ambroxol Hcl

abx188586-250g Abbexa 250 g 309.6 EUR

Minocycline Hcl

abx188790-10g Abbexa 10 g 927.6 EUR

Naphazoline Hcl

abx188809-1000g Abbexa 1000 g 2064 EUR

Prazosin HCl

20-abx185996 Abbexa
  • 292.80 EUR
  • 543.60 EUR
  • 100 mg
  • 1 g

Tetracycline HCl

20-abx186579 Abbexa
  • 343.20 EUR
  • 243.60 EUR
  • 100 g
  • 25 g

Methylamine HCl

abx187854-100g Abbexa 100 g 444 EUR

Chlorhexidine HCl

abx187869-1kg Abbexa 1 kg 1045.2 EUR

LP533401 hcl

B5823-25 ApexBio 25 mg 1312.8 EUR
Description: LP533401 hcl is an inhibitor of Tph-1 [1]. Tryptophan hydroxylase-1 (Tph-1) is an isoenzyme of tryptophan hydroxylase and the initial enzyme in gut- and lung-derived serotonin biosynthesis. Tph-1 is mainly expressed in the gut and lung [2].

LP533401 hcl

B5823-5 ApexBio 5 mg 547.2 EUR
Description: LP533401 hcl is an inhibitor of Tph-1 [1]. Tryptophan hydroxylase-1 (Tph-1) is an isoenzyme of tryptophan hydroxylase and the initial enzyme in gut- and lung-derived serotonin biosynthesis. Tph-1 is mainly expressed in the gut and lung [2].

LX7101 HCL

B5863-10 ApexBio 10 mg 927.6 EUR
Description: Description:IC50: 4.3, 32, 69 and 32 nM for LIMK2, KIMK1, ROCK1 and ROCK2, respectivleyLIM-kinases 1 and 2 (LIMK1 and LIMK2) regulate cytoskeletal dynamics by phosphorylating and deactivating cofilin, a protein that depolymerizes actin filaments.

LX7101 HCL

B5863-100 ApexBio 100 mg 4837.2 EUR
Description: Description:IC50: 4.3, 32, 69 and 32 nM for LIMK2, KIMK1, ROCK1 and ROCK2, respectivleyLIM-kinases 1 and 2 (LIMK1 and LIMK2) regulate cytoskeletal dynamics by phosphorylating and deactivating cofilin, a protein that depolymerizes actin filaments.

LX7101 HCL

B5863-5 ApexBio 5 mg 582 EUR
Description: Description:IC50: 4.3, 32, 69 and 32 nM for LIMK2, KIMK1, ROCK1 and ROCK2, respectivleyLIM-kinases 1 and 2 (LIMK1 and LIMK2) regulate cytoskeletal dynamics by phosphorylating and deactivating cofilin, a protein that depolymerizes actin filaments.

LX7101 HCL

B5863-5.1 ApexBio 10 mM (in 1mL DMSO) 576 EUR
Description: Description:IC50: 4.3, 32, 69 and 32 nM for LIMK2, KIMK1, ROCK1 and ROCK2, respectivleyLIM-kinases 1 and 2 (LIMK1 and LIMK2) regulate cytoskeletal dynamics by phosphorylating and deactivating cofilin, a protein that depolymerizes actin filaments.

LX7101 HCL

B5863-50 ApexBio 50 mg 3099.6 EUR
Description: Description:IC50: 4.3, 32, 69 and 32 nM for LIMK2, KIMK1, ROCK1 and ROCK2, respectivleyLIM-kinases 1 and 2 (LIMK1 and LIMK2) regulate cytoskeletal dynamics by phosphorylating and deactivating cofilin, a protein that depolymerizes actin filaments.

SCH772984 HCl

B5866-10 ApexBio 10 mg 309.6 EUR
Description: SCH772984 HCl

SCH772984 HCl

B5866-25 ApexBio 25 mg 560.4 EUR
Description: SCH772984 HCl

SCH772984 HCl

B5866-5 ApexBio 5 mg 226.8 EUR
Description: SCH772984 HCl

SCH772984 HCl

B5866-5.1 ApexBio 10 mM (in 1mL DMSO) 574.8 EUR
Description: SCH772984 HCl

SCH772984 HCl

B5866-50 ApexBio 50 mg 950.4 EUR
Description: SCH772984 HCl

Carteolol HCl

B5944-100 ApexBio 100 mg 1034.4 EUR
Description: Beta-adrenergic antagonist are an important class of drugs for the treatment of various heart diseases, such as high blood pressure, insufficiency of blood flow to the heart muscle, irregular heart beat, thickened heart muscle, and decreased ability of the heart to empty or fill normally.

Carteolol HCl

B5944-25 ApexBio 25 mg 547.2 EUR
Description: Beta-adrenergic antagonist are an important class of drugs for the treatment of various heart diseases, such as high blood pressure, insufficiency of blood flow to the heart muscle, irregular heart beat, thickened heart muscle, and decreased ability of the heart to empty or fill normally.

Carteolol HCl

B5944-5 ApexBio 5 mg 254.4 EUR
Description: Beta-adrenergic antagonist are an important class of drugs for the treatment of various heart diseases, such as high blood pressure, insufficiency of blood flow to the heart muscle, irregular heart beat, thickened heart muscle, and decreased ability of the heart to empty or fill normally.

Carteolol HCl

B5944-5.1 ApexBio 10 mM (in 1mL DMSO) 268.8 EUR
Description: Beta-adrenergic antagonist are an important class of drugs for the treatment of various heart diseases, such as high blood pressure, insufficiency of blood flow to the heart muscle, irregular heart beat, thickened heart muscle, and decreased ability of the heart to empty or fill normally.

Cyclobenzaprine HCl

B5994-1000 ApexBio 1 g 157.2 EUR
Description: Cyclobenzaprine is a 5-HT2 receptor antagonist and inhibitor, in some article, cyclobenzaprine hydrochloride was used as the compound to research in cyclobenzaprine.

Cyclobenzaprine HCl

B5994-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Cyclobenzaprine is a 5-HT2 receptor antagonist and inhibitor, in some article, cyclobenzaprine hydrochloride was used as the compound to research in cyclobenzaprine.

Cyclobenzaprine HCl

B5994-5000 ApexBio 5 g 448.8 EUR
Description: Cyclobenzaprine is a 5-HT2 receptor antagonist and inhibitor, in some article, cyclobenzaprine hydrochloride was used as the compound to research in cyclobenzaprine.

SKF38393 HCl

B6030-100 ApexBio 100 mg 192 EUR
Description: SKF38393 HCl (SKF38393) is a selective dopamine D1 receptor agonist [1], with an IC50 value of 110 nM [2].There are two functional types of dopamine receptors, D1 and D2 receptors [3]. The stimulation of the D1 receptor (D1R) in prefrontal cortex (PFC) results in an ?inverted-U? dose-response.

SKF38393 HCl

B6030-200 ApexBio 200 mg 282 EUR
Description: SKF38393 HCl (SKF38393) is a selective dopamine D1 receptor agonist [1], with an IC50 value of 110 nM [2].There are two functional types of dopamine receptors, D1 and D2 receptors [3]. The stimulation of the D1 receptor (D1R) in prefrontal cortex (PFC) results in an ?inverted-U? dose-response.

SKF38393 HCl

B6030-500 ApexBio 500 mg 547.2 EUR
Description: SKF38393 HCl (SKF38393) is a selective dopamine D1 receptor agonist [1], with an IC50 value of 110 nM [2].There are two functional types of dopamine receptors, D1 and D2 receptors [3]. The stimulation of the D1 receptor (D1R) in prefrontal cortex (PFC) results in an ?inverted-U? dose-response.

Tedizolid HCl

B6049-10 ApexBio 10 mg 309.6 EUR
Description: IC50: for MAO-A (monoamine oxidase-A), 8.7 uM; for MAO-B, 5.7 uM.Tedizolid HCl is a reversible, novel oxazolidinone antibiotic. It is the first oxazolidinone to be approved since linezolid in 2000.

Tedizolid HCl

B6049-5 ApexBio 5 mg 226.8 EUR
Description: IC50: for MAO-A (monoamine oxidase-A), 8.7 uM; for MAO-B, 5.7 uM.Tedizolid HCl is a reversible, novel oxazolidinone antibiotic. It is the first oxazolidinone to be approved since linezolid in 2000.

Tedizolid HCl

B6049-50 ApexBio 50 mg 783.6 EUR
Description: IC50: for MAO-A (monoamine oxidase-A), 8.7 uM; for MAO-B, 5.7 uM.Tedizolid HCl is a reversible, novel oxazolidinone antibiotic. It is the first oxazolidinone to be approved since linezolid in 2000.

Epinephrine HCl

B1327-200 ApexBio 200 mg 224.4 EUR
Description: Epinephrine HCl is a hormone and a neurotransmitter.

Epinephrine HCl

B1327-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Epinephrine HCl is a hormone and a neurotransmitter.

Epinephrine HCl

B1327-50 ApexBio 50 mg 153.6 EUR
Description: Epinephrine HCl is a hormone and a neurotransmitter.

Tolazoline HCl

B1329-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Tolazoline is a non-selective competitive ?-adrenergic receptor antagonist.

Tolazoline HCl

B1329-50 ApexBio 50 mg 153.6 EUR
Description: Tolazoline is a non-selective competitive ?-adrenergic receptor antagonist.

Acebutolol HCl

B1330-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Acebutolol is a ?-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.

Acebutolol HCl

B1330-50 ApexBio 50 mg 153.6 EUR
Description: Acebutolol is a ?-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.

Acebutolol HCl

B1330-S ApexBio Evaluation Sample 97.2 EUR
Description: Acebutolol is a ?-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.

Adrenalone HCl

B1331-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.

Adrenalone HCl

B1331-50 ApexBio 50 mg 153.6 EUR
Description: Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.

Adrenalone HCl

B1331-S ApexBio Evaluation Sample 97.2 EUR
Description: Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.

Clonidine HCl

B1333-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Clonidine Hydrochloride is a centrally acting alpha-agonist hypotensive agent.

Clonidine HCl

B1333-50 ApexBio 50 mg 153.6 EUR
Description: Clonidine Hydrochloride is a centrally acting alpha-agonist hypotensive agent.

Clonidine HCl

B1333-S ApexBio Evaluation Sample 97.2 EUR
Description: Clonidine Hydrochloride is a centrally acting alpha-agonist hypotensive agent.

Isoprenaline HCl

B1336-100000 ApexBio 100 g 408 EUR
Description: Isoprenaline HCl is an agonist of ?-adrenergic receptor [1].The adrenergic receptors are a class of G protein-coupled receptors that are targets of norepinephrine and epinephrine.

Isoprenaline HCl

B1336-25000 ApexBio 25 g 205.2 EUR
Description: Isoprenaline HCl is an agonist of ?-adrenergic receptor [1].The adrenergic receptors are a class of G protein-coupled receptors that are targets of norepinephrine and epinephrine.

Isoprenaline HCl

B1336-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Isoprenaline HCl is an agonist of ?-adrenergic receptor [1].The adrenergic receptors are a class of G protein-coupled receptors that are targets of norepinephrine and epinephrine.

Maprotiline HCl

B1338-5.1 ApexBio 10 mM (in 1mL DMSO) 129.6 EUR
Description: Maprotiline HCl
×

Moreover, a number of different compounds are recognized (e.g., ethanol) that correlate with inhabitants density and originate from a number of VCP sources. Ethanol and fragrances are amongst the most considerable and reactive VOCs related to VCP emissions.

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