Research have reported that the incidence of ocular discomfort in individuals who usually put on make-up is larger than that in the regular inhabitants. The incidence of ocular discomfort of those folks could also be additionally associated to the every day ocular exposure to chemical surfactants throughout cleaning.
The aims of this research have been to discover morphological and pathological modifications in the murine ocular floor after low-dose repeated exposure to disodium cocoamphodiacetate (DC), a form of chemical surfactant extensively utilized in personal cleaning products, and to examine the doable mechanisms. DC was administered in low dose (0.1%) to the ocular floor of C56BL/6 as soon as every day for 2 weeks
. We discovered that there have been a rise of sodium fluorescein staining on the cornea, a major thinning of corneal epithelial thickness, and elevated TUNEL-positive cells in corneal epithelium in vivo. DC therapy additionally modulated the distribution of Okay14+ and P63+ epithelia from the limbal to the middle on the cornea. In cultured murine corneal epithelial progenitor cell line (TKE2), DC therapy induced cell detachment and decreased the activation of Ak pressure reworking protein (AKT), and extracellular signal-regulated kinase (ERK).
And DC elevated TUNEL-positive cells in vitro with elevated expression of cleaved Caspase3 and B-cell lymphoma-2 related X protein (Bax). Our outcomes indicated that repeated low-dose DC exposure on ocular floor brought about vital impairment on the construction and viability of the corneal epithelium by inhibiting epithelial proliferation and inducing apoptosis. It offers the foundations to perceive the dangerous results of cleaning products every day exposure on the ocular floor.
Chemical Composition and Purposeful Properties of Dietary Fibre Concentrates from Winemaking By-Products: Skins, Stems and Lees
The target of this research was to consider, from a technological and dietary perspective, the chemical composition and practical properties of the industrial winemaking by-products, specifically skins, stems and lees. The chemical and bodily traits, in addition to the practical properties (fats and water retention and swelling capability, antioxidant capability, and their prebiotic impact), of the dietary fibre of those by-products have been studied.
The outcomes confirmed that the skins, stems, and lees are wealthy in fibre, with the stem fibre containing the highest quantities of non-extractable polyphenols hooked up to polysaccharides with excessive antioxidant exercise and prebiotic impact. Lee fibre had the highest water retention capability and oil retention capability.
The outcomes reveal that winemaking by-products might be used as a supply of dietary fibre with practical traits for meals functions. We collected experimental knowledge on chemical migration from completely different products into saliva for a number of substance teams and supplies, figuring out chemical focus and diffusion coefficient as foremost properties of affect.
To foretell migration charges into saliva, we tailored a beforehand developed migration mannequin for chemical substances in meals packaging supplies. We additionally developed a regression mannequin based mostly on recognized chemical and materials properties.
Chemical security evaluation of transformation products of landfill leachate fashioned throughout the Fenton course of
Natural chemical substances recognized in uncooked landfill leachate (LL) and their transformation products (TPs), fashioned throughout Fenton therapy, have been analyzed for chemical security following REACH tips. The uncooked LL was situated in the metropolitan area of Campina Grande, in northeast Brazil.
We elucidated 197 distinctive chemical constructions, together with 154 compounds that have been current in uncooked LL and 82 compounds that have been detected in the handled LL, totaling 39 persistent compounds and 43 TPs. In silico fashions have been developed to establish and prioritize the potential degree of hazard/danger these compounds pose to the atmosphere and society. The fashions revealed that the Fenton course of improved the biodegradability of TPs.
Nonetheless, a slight enhance in ecotoxicological results was noticed amongst the compounds in handled LL in contrast with these current in uncooked LL. No variations have been noticed for aryl hydrocarbon receptor (AhR) and antioxidant response factor (ARE) mutagenicity. Comparable conduct amongst each uncooked and handled LL samples was noticed for biodegradability; Tetrahymena pyriformis, Daphnia magna, Pimephales promelas and ARE, AhR, and Ames mutagenicity. Total, our outcomes counsel that uncooked and handled LL samples have related exercise profiles for all endpoints apart from biodegradability.
NP Navigator: a New Take a look at the Pure Product Chemical Area
Pure products (NPs), being evolutionary chosen over thousands and thousands of years to bind to organic macromolecules, remained an essential supply of inspiration for medicinal chemists even after the introduction of environment friendly drug discovery applied sciences corresponding to combinatorial chemistry and high-throughput screening.
Thus, there’s a sturdy demand for environment friendly and user-friendly computational instruments that enable to analyze giant libraries of NPs. On this context, we introduce NP Navigator – a freely accessible intuitive on-line software for visualization and navigation by the chemical house of NPs and NP-like molecules. It’s based mostly on the hierarchical ensemble of generative topographic maps, that includes NPs from the COlleCtion of Open NatUral producTs (COCONUT), bioactive compounds from ChEMBL and commercially accessible molecules from ZINC.
Mouse DNA Repair Primer Library II |
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| MDRL-II | Real Time Primers | 1 set | 645 EUR |
Human Cancer Driver Gene II Primer Library |
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| HCDG-II | Real Time Primers | 1 set | 645 EUR |
Human Interferon Type II Signaling Primer Library |
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| HIFN-II | Real Time Primers | 1 set | 548 EUR |
Rat ANG II (Angiotensin II) ELISA Kit |
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| ER1637 | FN Test | 96T | 567.6 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 18.75pg/ml |
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Rabbit ANG II(Angiotensin II) ELISA Kit |
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| ERB0006 | FN Test | 96T | 567.6 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rabbit;Sensitivity: 18.75pg/ml |
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Human ANG II(Angiotensin II) ELISA Kit |
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| EH2627 | FN Test | 96T | 524.1 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml |
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Rat HC II(Heparin Cofactor II) ELISA Kit |
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| ER1032 | FN Test | 96T | 524.1 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 18.75pg/ml |
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Mouse F II(coagulation factor II) ELISA Kit |
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| EM1012 | FN Test | 96T | 524.1 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml |
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Mouse HC II(Heparin Cofactor II) ELISA Kit |
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| EM1108 | FN Test | 96T | 524.1 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 18.75pg/ml |
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Human Herpes Simplex Virus Type II (HSVII) IgG Rapid Test Kit |
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| abx092095-20tests | Abbexa | 20 tests | 217 EUR |
NDV rapid test kit |
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| RG15-03 | Bionote | 1 box | 139.05 EUR |
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Description: Please check the datasheet of NDV rapid test kit before using the test. |
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Melamine Rapid Test Kit |
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| abx092011-50tests | Abbexa | 50 tests | 370 EUR |
Human ProCollagen II ELISA Kit |
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| EH4704 | FN Test | 96T | 567.6 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml |
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Accu-Tell COVID-19 IgG/IgM Rapid Test |
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| GEN-B352-20tests | Accu test | 20 tests | 236 EUR |
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Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus. |
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Accu-Tell COVID-19 IgG/IgM Rapid Test |
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| GEN-B352-40tests | Accu test | 40 tests | 321 EUR |
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Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus. |
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Frit Kit |
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| FRIT-KIT | Next Advance | 1each | 124 EUR |
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Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool. |
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Human SCG2(Secretogranin II) ELISA Kit |
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| EH3751 | FN Test | 96T | 524.1 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.75 ng/ml |
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Human ANG II R1-Ab(Angiotensin II Receptor 1 Antibody) ELISA Kit |
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| EH2629 | FN Test | 96T | 524.1 EUR |
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Description: Method of detection: Sandwich ELISA, Double Antigen;Reacts with: Homo sapiens;Sensitivity: 1.875 ng/ml |
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Column Packing Kit |
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| PACK-KIT | Next Advance | 1pack | 1035 EUR |
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Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar. |
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Attoglow Western Blot Analysis Kit- with Millennium Enhancer, Anti rabbit secondary antibody |
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| K3171120-II | Biochain | 1200 cm2 | 246 EUR |
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Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
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Attoglow Western Blot Analysis Kit- with Millennium Enhancer, Anti rabbit secondary antibody |
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| K3171250-II | Biochain | 2500 cm2 | 310 EUR |
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Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
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RapidSeq High Yield Directional mRNA Sample Prep Kit - With Aligner 13-24 |
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| KS073012-II | Biochain | 1 Kit | 1142 EUR |
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Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol. |
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RapidSeq High Yield Small RNA Sample Prep Kit - With Aligner 13-24 |
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| KS074012-II | Biochain | 1 Kit | 1021 EUR |
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Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol. |
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PCR Mycoplasma Detection Kit |
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| M034-Kit | TOKU-E | Kit | 266 EUR |
Rat CTX-II(Cross Linked C-telopeptide of Type II Collagen) ELISA Kit |
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| ER0877 | FN Test | 96T | 524.1 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.094 ng/ml |
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Human Cytomegalovirus, Toxoplasma, Rubella, Herpes simplex virus type II IgM Rapid Test Kit |
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| abx092077-20tests | Abbexa | 20 tests | 342 EUR |
Tetrodotoxin (TTX) ELISA Test Kit |
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| DEIANJ48 | Creative Diagnostics | 96T | 1625 EUR |
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Description: This test kit is for the quantitative detection of Tetrodotoxin in the tissue, liver, fish. |
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PCRAgH5 AIV Detection Test Kit |
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| PD55-02 | Bionote | 1 kit | 902.47 EUR |
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Description: Please check the datasheet of PCRAgH5 AIV Detection Test Kit before using the test. |
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Rapid Leishmania Ab Test Kit |
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| RB2104 | Bionote | 1 box | 127 EUR |
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Description: Please check the datasheet of Rapid Leishmania Ab Test Kit before using the test. |
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Rapid PED Ag Test Kit |
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| RG14-01 | Bionote | 1 box | 159.9 EUR |
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Description: Please check the datasheet of Rapid PED Ag Test Kit before using the test. |
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Melamine (MEL) Rapid Test Kit |
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| abx092057-50tests | Abbexa | 50 tests | 370 EUR |
Clenbuterol (CLE) Rapid Test Kit |
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| abx092058-50tests | Abbexa | 50 tests | 244 EUR |
Ractopamine (RAC) Rapid Test Kit |
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| abx092059-50tests | Abbexa | 50 tests | 244 EUR |
Salbutamol (SAL) Rapid Test Kit |
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| abx092060-50tests | Abbexa | 50 tests | 244 EUR |
Tetracycline (TCs) Rapid Test Kit |
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| abx092063-50tests | Abbexa | 50 tests | 398 EUR |
Sulfonamides (Sas) Rapid Test Kit |
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| abx092064-40tests | Abbexa | 40 tests | 398 EUR |
Quinolones (QNs) Rapid Test Kit |
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| abx092065-40tests | Abbexa | 40 tests | 398 EUR |
Ciprofloxacin (CPFX) Rapid Test Kit |
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| abx092066-50tests | Abbexa | 50 tests | 398 EUR |
Quinolones (QNs) Rapid Test Kit |
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| abx092067-40tests | Abbexa | 40 tests | 398 EUR |
Brucella Antibody Rapid Test Kit |
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| abx092069-40tests | Abbexa | 40 tests | 356 EUR |
Antibody ISOTYPING TEST KIT (OKSA11303) |
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| OKSA11303 | Aviva Systems Biology | 10 Tests | 780 EUR |
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Description: Description of target: MOUSE MONOCLONAL ANTIBODY ISOTYPING TEST KIT;Species reactivity: Mouse;Application: IS;Assay info: ;Sensitivity: |
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Rat Apoa2(Apolipoprotein A-II) ELISA Kit |
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| ER0688 | FN Test | 96T | 476.25 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 3.75 ng/ml |
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Rat CA2(Carbonic Anhydrase II) ELISA Kit |
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| ER0792 | FN Test | 96T | 524.1 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 1.688 ng/ml |
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Human U-II(Urotensin 2) ELISA Kit |
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| EH0340 | FN Test | 96T | 567.6 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml |
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Human APOC2(Apolipoprotein C-II) ELISA Kit |
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| EH0619 | FN Test | 96T | 476.25 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 1.875 ng/ml |
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Human APOA2(Apolipoprotein A-II) ELISA Kit |
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| EH0633 | FN Test | 96T | 476.25 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 37.5 ng/ml |
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Monkey CA2(Carbonic Anhydrase II) ELISA Kit |
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| EMK0013 | FN Test | 96T | 567.6 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Ape;Sensitivity: 1.875 ng/ml |
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DNASE TEST AGAR |
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| D04-101-10kg | Alphabiosciences | 10 kg | Ask for price |
DNASE TEST AGAR |
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| D04-101-2Kg | Alphabiosciences | 2 Kg | Ask for price |
DNASE TEST AGAR |
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| D04-101-500g | Alphabiosciences | 500 g | Ask for price |
DERMATOPHYTE TEST AGAR |
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| D04-107-10kg | Alphabiosciences | 10 kg | 849 EUR |
DERMATOPHYTE TEST AGAR |
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| D04-107-2Kg | Alphabiosciences | 2 Kg | 224 EUR |
DERMATOPHYTE TEST AGAR |
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| D04-107-500g | Alphabiosciences | 500 g | 97 EUR |
MOTILITY TEST MEDIUM |
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| M13-121-10kg | Alphabiosciences | 10 kg | 1528 EUR |
MOTILITY TEST MEDIUM |
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| M13-121-2Kg | Alphabiosciences | 2 Kg | 371 EUR |
MOTILITY TEST MEDIUM |
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| M13-121-500g | Alphabiosciences | 500 g | 137 EUR |
SAM Test Strip |
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| TS00201s-30 | Arthus | 30 tests | 416 EUR |
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Description: S-adenosylmethionine quantitative test strip for serum, plasma and whole blood |
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SAH Test Strip |
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| TS00301s-30 | Arthus | 30 tests | 504 EUR |
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Description: S-adenosylhomocysteine quantitative test strip for serum, plasma and whole blood |
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HCY Test Strip |
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| TS00401s-30 | Arthus | 30 tests | 553 EUR |
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Description: Serum homocysteine quantitative test strip |
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SNYDER TEST AGAR |
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| S19-119-10kg | Alphabiosciences | 10 kg | 1049 EUR |
SNYDER TEST AGAR |
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| S19-119-2Kg | Alphabiosciences | 2 Kg | 267 EUR |
SNYDER TEST AGAR |
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| S19-119-500g | Alphabiosciences | 500 g | 109 EUR |
Guinea pig CTX-II(Cross Linked C-telopeptide of Type II Collagen) ELISA Kit |
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| EGP0010 | FN Test | 96T | 567.6 EUR |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Guinea pig;Sensitivity: 0.094 ng/ml |
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Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit |
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| CAS400A-KIT | SBI | 1 kit (10 rxn) | 1110 EUR |
2019-nCoV IgG/IgM Rapid Test Cassette (Whole Blood/Serum/Plasma) |
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| GEN-402-25tests | All test | 25 tests | 244 EUR |
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Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus. |
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anti- EMAP II antibody |
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| FNab02750 | FN Test | 100µg | 548.75 EUR |
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Description: Antibody raised against EMAP II |
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anti- Pepsinogen II antibody |
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| FNab06309 | FN Test | 100µg | 505.25 EUR |
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Description: Antibody raised against Pepsinogen II |
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anti- CGRP-II antibody |
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| FNab09768 | FN Test | 100µg | 548.75 EUR |
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Description: Antibody raised against CGRP-II |
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CMV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV100PA-KIT | SBI | 1 Kit | 1132 EUR |
CMV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV105PA-KIT | SBI | 1 Kit | 1132 EUR |
MSCV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV120PA-KIT | SBI | 1 Kit | 1132 EUR |
MSCV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV125PA-KIT | SBI | 1 Kit | 1132 EUR |
Human DIO2(Type II iodothyronine deiodinase) ELISA Kit |
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| EH0963 | FN Test | 96T | 567.6 EUR |
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Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml |
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Multiplex gRNA Kit + EF1-T7-hspCas9-H1-gRNA linearized SmartNuclease vector |
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| CAS700A-KIT | SBI | 10 rxn | 1132 EUR |
Multiplex gRNA Kit + CAG-T7-hspCas9-H1-gRNA linearized SmartNuclease vector |
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| CAS720A-KIT | SBI | 10 rxn | 1132 EUR |
Multiplex gRNA Kit + CMV-T7-hspCas9-H1-gRNA linearized SmartNuclease vector |
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| CAS740A-KIT | SBI | 10 rxn | 1132 EUR |
T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents) |
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| CAS510A-KIT | SBI | 1 Kit | 805 EUR |
Anigen Rapid FIV Ab Test Kit |
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| RB22-01-DD | Bionote | 10 tests/Kit | 129.8 EUR |
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Description: Please check the datasheet of Anigen Rapid FIV Ab Test Kit before using the test. |
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Rapid Bovine Brucella Ab Test Kit |
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| RB23-01-DD | Bionote | 1 kit/10 tests | 151.79 EUR |
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Description: Please check the datasheet of Rapid Bovine Brucella Ab Test Kit before using the test. |
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Rapid Bovine TB Ab Test Kit |
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| RB23-02-DD | Bionote | 1 box | 128.4 EUR |
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Description: Please check the datasheet of Rapid Bovine TB Ab Test Kit before using the test. |
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Rapid FMD NSP Ab Test Kit |
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| RB28-02-DD | Bionote | 1 box | 135.4 EUR |
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Description: Please check the datasheet of Rapid FMD NSP Ab Test Kit before using the test. |
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AgRapidFeLV Ag/FIV Ab Test Kit |
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| RC12-04 | Bionote | 10 tests/kit | 170.4 EUR |
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Description: Please check the datasheet of AgRapidFeLV Ag/FIV Ab Test Kit before using the test. |
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Ag rapid CDV Ag Test Kit |
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| RG11-03 | Bionote | 1 box | 138.2 EUR |
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Description: Please check the datasheet of Ag rapid CDV Ag Test Kit before using the test. |
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Rapid TGE/PED Ag Test Kit |
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| RG14-03 | Bionote | 1 box | 240.85 EUR |
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Description: Please check the datasheet of Rapid TGE/PED Ag Test Kit before using the test. |
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Ag Rapid AIV Ag Test Kit |
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| RG15-01 | Bionote | 1 box/30 tests | 267 EUR |
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Description: Please check the datasheet of Ag Rapid AIV Ag Test Kit before using the test. |
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Ag Rapid H5AIV Ag test kit |
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| RG15-05 | Bionote | 1 box | 463 EUR |
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Description: Please check the datasheet of Ag Rapid H5AIV Ag test kit before using the test. |
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Clenbuterol Rapid Test Kit (Colloidal gold) |
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| abx092040-50tests | Abbexa | 50 tests | 272 EUR |
Ractopamine Rapid Test Kit (Colloidal gold) |
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| abx092042-50tests | Abbexa | 50 tests | 300 EUR |
Salbutamol Rapid Test Kit (Colloidal gold) |
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| abx092043-50tests | Abbexa | 50 tests | 342 EUR |
Chloramphenicol Rapid Test Kit (Colloidal gold) |
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| abx092045-50tests | Abbexa | 50 tests | 356 EUR |
Quinolones Rapid Test Kit (Colloidal gold) |
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| abx092046-50tests | Abbexa | 50 tests | 537 EUR |
Sulfonamides Rapid Test Kit (Colloidal gold) |
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| abx092047-50tests | Abbexa | 50 tests | 551 EUR |
NP Navigator permits to effectively analyze completely different features of NPs – chemotype distribution, physicochemical properties, organic exercise and business availability of NPs. The latter issues not solely purchasable NPs but additionally their shut analogs that may be thought of as artificial mimetics of NPs or pseudo-NPs.